A study of diet and health in the elderly; the gut microbiota as a source of bioactive agents

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dc.contributor.advisor Fitzgerald, Gerald F. en
dc.contributor.advisor O'Toole, Paul W. en
dc.contributor.advisor Ross, R. Paul en
dc.contributor.author Power, Susan Eleanor
dc.date.accessioned 2014-03-19T16:26:14Z
dc.date.issued 2013
dc.date.submitted 2013
dc.identifier.citation Power, S. E. 2013. A study of diet and health in the elderly; the gut microbiota as a source of bioactive agents. PhD Thesis, University College Cork. en
dc.identifier.endpage 275
dc.identifier.uri http://hdl.handle.net/10468/1477
dc.description.abstract The global proportion of older persons is increasing rapidly. Diet and the intestinal microbiota independently and jointly contribute to health in the elderly. The habitual dietary patterns and functional microbiota components of elderly subjects were investigated in order to identify specific effector mechanisms. A study of the dietary intake of Irish community-dwelling elderly subjects showed that the consumption of foods high in fat and/or sugar was excessive, while consumption of dairy foods was inadequate. Elderly females typically had a more nutrient- dense diet than males and a considerable proportion of subjects, particularly males, had inadequate intakes of calcium, magnesium, vitamin D, folate, zinc and vitamin C. The association between dietary patterns, glycaemic index and cognitive function was also investigated. Elderly subjects consuming ‘prudent’ dietary patterns had better cognitive function compared to those consuming ‘Western’ dietary patterns. Furthermore, fully-adjusted regression models revealed that a high glycaemic diet was associated with poor cognitive function, demonstrating a new link between nutrition and cognition. An extensive screening study of the elderly faecal-derived microbiota was also undertaken to examine the prevalence of antimicrobial production by intestinal bacteria. A number of previously characterised bacteriocins were isolated (gassericin T, ABP-118, mutacin II, enterocin L-50 and enterocin P) in this study. Interestingly, a Lactobacillus crispatus strain was found to produce a potentially novel antimicrobial compound. Full genome sequencing of this strain revealed the presence of three loci which exhibited varying degrees of homology with the genes responsible for helveticin J production in Lb. helveticus. An additional study comparing the immunomodulatory capacity of ‘viable’ and ‘non-viable’ Bifidobacterium strains found that Bifidobacterium-fermented milks (BFMs) containing ‘non-viable’ cells could stimulate levels of IL-10 and TNF-α in a manner similar to those stimulated by BFMs containing ‘viable’ cells in vitro. en
dc.description.sponsorship Enterprise Partnership Scheme (Alimentary Health-industry sponsor); SFI grant no. 07/CE/B1368 en
dc.description.sponsorship Irish Research Council (Enterprise Partnership Scheme - Alimentary Health Ltd.) en
dc.description.sponsorship Science Foundation Ireland (Alimentary Pharmabiotic Centre 07/CE/B1368) en
dc.description.sponsorship Department of Agriculture, Food and the Marine, Ireland (ELDERMET) en
dc.description.sponsorship Health Research Board (Food Health Research Initiative) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2013, Susan E. Power en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Diet en
dc.subject Microbiota en
dc.subject Elderly en
dc.subject Bacteriocin en
dc.subject.lcsh Older people--Nutrition en
dc.subject.lcsh Bacteriocins
dc.title A study of diet and health in the elderly; the gut microbiota as a source of bioactive agents en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral Degree (Structured) en
dc.type.qualificationname PhD (Science) en
dc.internal.availability Full text available en
dc.description.version Accepted Version
dc.contributor.funder Irish Research Council en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Department of Agriculture, Food and the Marine, Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Teagasc
dc.description.status Not peer reviewed en
dc.internal.school Microbiology en
dc.check.reason Releasing this thesis would cause substantial prejudice to the commercial interests of the sponsor of the postgraduate research en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.chapterOfThesis Chapter 5
dc.check.embargoformat Both hard copy thesis and e-thesis en
ucc.workflow.supervisor g.fitzgerald@ucc.ie
dc.internal.conferring Spring Conferring 2014 en

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