Biosensors using photonic crystal fibres

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dc.contributor.advisor Gunning, Fatima C. Garcia en
dc.contributor.advisor Ellis, Andrew D. en
dc.contributor.author Rutowska, Monika S.
dc.date.accessioned 2014-04-09T14:47:04Z
dc.date.available 2014-04-09T14:47:04Z
dc.date.issued 2014
dc.date.submitted 2014
dc.identifier.citation Rutowska, M. S. 2014. Biosensors using photonic crystal fibres. PhD Thesis, University College Cork. en
dc.identifier.endpage 152
dc.identifier.uri http://hdl.handle.net/10468/1511
dc.description.abstract In this thesis, we present the unique properties of hollow-core photonic crystal fibres (HC-PCFs) for sensing applications in terms of viscosity detection and DNA sensing using a special poly(ethylene) glycol (PEGDA) hydrogel. The low loss HC-PCFs ensure a long interaction length between the sample and the optical signals. Thus in this thesis, we report the characterisation of filled HC-PCFs and the development of a selective filling process. For the first time, we report the investigation of a new viscometer device, and a new device for DNA sensing development, and also the chemical process for hydrogel growth was adapted to the fibres. By combining HC-PCFs with the hydrogel we enable 3D volumetric sample confinement within the HC-PCF, further increasing the interaction between the sample and the optical signal. However, the hydrogel has a large influence on the guidance properties of the HC-PCF and the HC-PCF has a strong influence on the growth process for the hydrogel itself. When we integrate the hydrogel and HC-PCFs we detect concentration levels as low as 400 nM of labelled DNA. However, using our technology for fluorescence detection we can achieve results two orders of magnitude better than those previously reported. en
dc.description.sponsorship Science Foundation Ireland (06/IN/1969) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2014, Monika S. Rutowska en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Photonic crystal fibre en
dc.subject Sensing en
dc.subject Hydrogel en
dc.subject Viscosity en
dc.subject.lcsh Biosensors en
dc.subject.lcsh Photonics en
dc.title Biosensors using photonic crystal fibres en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Science) en
dc.internal.availability Full text available en
dc.check.info No embargo required en
dc.description.version Accepted Version
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder The OakWood en
dc.contributor.funder Compuserv GmbH, Germany en
dc.description.status Not peer reviewed en
dc.internal.school Physics en
dc.internal.school Tyndall National Institute en
dc.check.type No Embargo Required
dc.check.reason No embargo required en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.embargoformat Not applicable en
ucc.workflow.supervisor fatima.gunning@tyndall.ie
dc.internal.conferring Summer Conferring 2014


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© 2014, Monika S. Rutowska Except where otherwise noted, this item's license is described as © 2014, Monika S. Rutowska
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