The impact of a variety of factors on the obesity associated gut microbiota

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dc.contributor.advisor O'Toole, Paul W. en
dc.contributor.advisor Cotter, Paul D. en Clarke, Siobhan F. 2014-05-12T14:09:20Z 2015-05-13T04:00:05Z 2013 2013
dc.identifier.citation Clarke, S. F. 2013. The impact of a variety of factors on the obesity associated gut microbiota. PhD Thesis, University College Cork. en
dc.identifier.endpage 342
dc.description.abstract The obesity pandemic has become perhaps the most prevalent health issue of our time, with more than 10% of the world’s population now being obese. Obesity can be defined as abnormal or excess fat accumulation that may impair health and results from an imbalance between energy intake and energy expenditure. A decrease in physical activity due to an increase in sedentary forms of work, changing modes of transport and increasing urbanization is likely a major contributory factor. Diet is another major factor with the increased availability and intake of calorie dense, high fat foods being of global concern. Notably, with respect to this thesis, over the last decade advances in the field of next generation sequencing (NGS) have facilitated investigations to determine the relationship between the gut microbiota and obesity. This thesis examines the impact of a variety of factors on the obesity associated gut microbiota. Overall the results presented in this thesis highlight that microbial diversity is influenced by diet, exercise, antibiotics and disease state, however it is only through further understanding of the structure and function that we can identify targets that can impact on health. en
dc.description.sponsorship Teagasc Walsh Fellowship en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2013, Siobhan F. Clarke. en
dc.rights.uri en
dc.subject Obesity en
dc.subject Gut microbiota en
dc.title The impact of a variety of factors on the obesity associated gut microbiota en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Science) en
dc.internal.availability Full text available en
dc.description.version Accepted Version
dc.contributor.funder Teagasc en
dc.description.status Not peer reviewed en Microbiology en
dc.check.reason This thesis is due for publication or the author is actively seeking to publish this material en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.entireThesis Entire Thesis Restricted
dc.check.embargoformat Both hard copy thesis and e-thesis en
dc.internal.conferring Summer Conferring 2014 en

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© 2013, Siobhan F. Clarke. Except where otherwise noted, this item's license is described as © 2013, Siobhan F. Clarke.
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