• Sensorimotor control of breathing in the mdx mouse model of Duchenne muscular dystrophy 

  Burns, David P.; Roy, Arijit; Lucking, Eric; McDonald, Fiona B.; Gray, Sam; Wilson, Richard J.; Edge, Deirdre; O'Halloran, Ken D. (John Wiley & Sons, Inc., 2017-09-26)

  Patients with Duchenne muscular dystrophy (DMD) hypoventilate with consequential arterial blood gas derangement relevant to disease progression. Whereas deficits in DMD diaphragm are recognized, there is a paucity of ...
• Diaphragm muscle weakness following acute sustained hypoxic stress in the mouse is prevented by pretreatment with N-acetyl cysteine 

  O'Leary, Andrew J.; Drummond, Sarah E.; Edge, Deirdre; O'Halloran, Ken D. (Hindawi Ltd., 2018)

  Oxygen deficit (hypoxia) is a major feature of cardiorespiratory diseases characterized by diaphragm dysfunction, yet the putative role of hypoxic stress as a driver of diaphragm dysfunction is understudied. We explored ...
• Development of an ex vivo method for multi-unit recording of microbiota-colonic-neural signaling in real time 

  Buckley, Maria M.; O'Malley, Dervla (Frontiers Media SA, 2018)

  Background and Objectives: Bidirectional signaling between the gastrointestinal tract and the brain is vital for maintaining whole-body homeostasis. Moreover, emerging evidence implicates vagal afferent signaling in the ...
• Interaction between nitric oxide and renal α1-adrenoreceptors mediated vasoconstriction in rats with left ventricular hypertrophyin Wistar Kyoto rats 

  Ahmad, Ashfaq; Sattar, Munavvar A.; Azam, Maleeha; Khan, Safia A.; Bhatt, Owais; Johns, Edward J. (Public Library of Science, 2018)

  Left ventricular hypertrophy (LVH) is associated with decreased responsiveness of renal alpha(1)-adrenoreceptors subtypes to adrenergic agonists. Nitric oxide donors are known to have antihypertrophic effects however their ...
• Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements 

  Wu, Sen; Mariotti, Marco; Santesmasses, Didac; Hill, Kristina E.; Baclaocos, Janinah; Aparicio-Prat, Estel; Li, Shuping; Mackrill, John; Wu, Yuanyuan; Howard, Michael T.; Capecchi, Mario; Guigó, Roderic; Burk, Raymond F.; Atkins, John F. (The Royal Society, 2016-11-23)

  Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3′ UTR structural elements (SECIS) and is regulated by selenium availability. ...

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