• The gut microbiome influences the bioavailability of olanzapine in rats. 

  Cussotto, Sofia; Walsh, Jacinta; Golubeva, Anna V.; Zhdanov, Alexander V.; Strain, Conall R.; Fouhy, Fiona; Stanton, Catherine; Dinan, Timothy G.; Hyland, Niall P.; Clarke, Gerard; Cryan, John F.; Griffin, Brendan T. (Elsevier, 2021-04-02)

  Background: The role of the gut microbiome in the biotransformation of drugs has recently come under scrutiny. It remains unclear whether the gut microbiome directly influences the extent of drug absorbed after oral ...
• The art of facilitation: a delicate hormonal balance! 

  McDonald, Fiona B. (John Wiley & Sons Ltd., 2021-07-23)
• Influence of innate immune activation on endocrine and metabolic pathways in infancy 

  O'Connor, Karen M.; Ashoori, Minoo; Dias, M. L.; Dempsey, Eugene M.; O'Halloran, Ken D.; McDonald, Fiona B. (American Physiological Society, 2021-04-26)

  Prematurity is the leading cause of neonatal morbidity and mortality worldwide. Premature infants often require extended hospital stays, with increased risk of developing infection compared with term infants. A picture is ...
• Time course and magnitude of ventilatory and renal acid-base acclimatization following rapid ascent to and residence at 3,800 m over nine days 

  Bird, Jordan D.; Leacy, Jack K.; Foster, Glen Edward; Rickards, Caroline A.; Wilson, Richard J. A.; O'Halloran, Ken D.; Jendzjowsky, Nicholas G.; Pentz, Brandon A.; Byman, Britta R. M.; Thrall, Scott F.; Skalk, Alexandra L.; Hewitt, Sarah A.; Steinback, Craig D.; Burns, David; Ondrus, Peter; Day, Trevor A. (American Physiological Society, 2021-03-11)

  Rapid ascent to high altitude imposes an acute hypoxic and acid-base challenge, with ventilatory and renal acclimatization countering these perturbations. Specifically, ventilatory acclimatization improves oxygenation, but ...
• Quinacrine and niclosamide promote neurite growth in midbrain dopaminergic neurons through the canonical BMP-Smad pathway and protect against neurotoxin and a-synuclein-induced neurodegeneration 

  Goulding, Susan R.; Lévesque, Martin; Sullivan, Aideen M.; Collins, Louise M.; O'Keeffe, Gerard W. (Springer, 2021-03-12)

  Parkinson's disease is a neurodegenerative disorder characterised by nigrostriatal dopaminergic degeneration, and intracellular a-synuclein aggregation. Current pharmacological treatments are solely symptomatic so there ...

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