• Influence of innate immune activation on endocrine and metabolic pathways in infancy 

  O'Connor, Karen M.; Ashoori, Minoo; Dias, M. L.; Dempsey, Eugene; O'Halloran, Ken D.; McDonald, Fiona B. (American Physiological Society, 2021-04-26)

  Prematurity is the leading cause of neonatal morbidity and mortality worldwide. Premature infants often require extended hospital stays, with increased risk of developing infection compared with term infants. A picture is ...
• Time course and magnitude of ventilatory and renal acid-base acclimatization following rapid ascent to and residence at 3,800 m over nine days 

  Bird, Jordan D.; Leacy, Jack K.; Foster, Glen Edward; Rickards, Caroline A.; Wilson, Richard J. A.; O'Halloran, Ken D.; Jendzjowsky, Nicholas G.; Pentz, Brandon A.; Byman, Britta R. M.; Thrall, Scott F.; Skalk, Alexandra L.; Hewitt, Sarah A.; Steinback, Craig D.; Burns, David; Ondrus, Peter; Day, Trevor A. (American Physiological Society, 2021-03-11)

  Rapid ascent to high altitude imposes an acute hypoxic and acid-base challenge, with ventilatory and renal acclimatization countering these perturbations. Specifically, ventilatory acclimatization improves oxygenation, but ...
• Quinacrine and niclosamide promote neurite growth in midbrain dopaminergic neurons through the canonical BMP-Smad pathway and protect against neurotoxin and a-synuclein-induced neurodegeneration 

  Goulding, Susan R.; Lévesque, Martin; Sullivan, Aideen M.; Collins, Louise M.; O'Keeffe, Gerard W. (Springer, 2021-03-12)

  Parkinson's disease is a neurodegenerative disorder characterised by nigrostriatal dopaminergic degeneration, and intracellular a-synuclein aggregation. Current pharmacological treatments are solely symptomatic so there ...
• Effects of intracerebroventricular leptin and orexin-A on the baroreflex control of renal sympathetic nerve activity in conscious rats fed a normal or high-fat diet 

  Huang, Chunlong; AlMarabeh, Sara; Cavers, Jeremy; Abdulla, Mohammed H.; Johns, Edward J. (John Wiley & Sons, Inc., 2020-12-22)

  This study examined the effect of leptin and orexin‐A on autonomic baroreflex control in conscious Wistar rats exposed to high‐fat (45% fat) or normal (3.4%) diet for 4 weeks. Renal sympathetic nerve activity (RSNA), mean ...
• Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer 

  Keane, Jonathan M.; Joyce, Susan A.; Gahan, Cormac G. M.; Hyland, Niall P.; Houston, Aileen (Springer Nature Switzerland AG, 2020-12-03)

  The symbiosis between the gut microbiota and the host has been identified as an integral part of normal human physiology and physiological development. Research in germ-free or gnotobiotic animals has demonstrated the ...

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