Development of low-cost sensing and separation devices based on macro, micro and nano technology for health applications

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dc.contributor.advisor Glennon, Jeremy D. en
dc.contributor.advisor Moore, Eric J. en
dc.contributor.author Crowley, Una Bernadette
dc.date.accessioned 2015-10-23T09:20:40Z
dc.date.available 2015-10-23T09:20:40Z
dc.date.issued 2014
dc.date.submitted 2014
dc.identifier.citation Crowley, U. B. 2014. Development of low-cost sensing and separation devices based on macro, micro and nano technology for health applications. PhD Thesis, University College Cork. en
dc.identifier.endpage 215
dc.identifier.uri http://hdl.handle.net/10468/2007
dc.description.abstract The work presented in this thesis described the development of low-cost sensing and separation devices with electrochemical detections for health applications. This research employs macro, micro and nano technology. The first sensing device developed was a tonerbased micro-device. The initial development of microfluidic devices was based on glass or quartz devices that are often expensive to fabricate; however, the introduction of new types of materials, such as plastics, offered a new way for fast prototyping and the development of disposable devices. One such microfluidic device is based on the lamination of laser-printed polyester films using a computer, printer and laminator. The resulting toner-based microchips demonstrated a potential viability for chemical assays, coupled with several detection methods, particularly Chip-Electrophoresis-Chemiluminescence (CE-CL) detection which has never been reported in the literature. Following on from the toner-based microchip, a three-electrode micro-configuration was developed on acetate substrate. This is the first time that a micro-electrode configuration made from gold; silver and platinum have been fabricated onto acetate by means of patterning and deposition techniques using the central fabrication facilities in Tyndall National Institute. These electrodes have been designed to facilitate the integration of a 3- electrode configuration as part of the fabrication process. Since the electrodes are on acetate the dicing step can automatically be eliminated. The stability of these sensors has been investigated using electrochemical techniques with excellent outcomes. Following on from the generalised testing of the electrodes these sensors were then coupled with capillary electrophoresis. The final sensing devices were on a macro scale and involved the modifications of screenprinted electrodes. Screen-printed electrodes (SPE) are generally seen to be far less sensitive than the more expensive electrodes including the gold, boron-doped diamond and glassy carbon electrodes. To enhance the sensitivity of these electrodes they were treated with metal nano-particles, gold and palladium. Following on from this, another modification was introduced. The carbonaceous material carbon monolith was drop-cast onto the SPE and then the metal nano-particles were electrodeposited onto the monolith material en
dc.description.sponsorship Science Foundation Ireland (SFI Grant 08/SRC/B1412, Irish Separation Science Cluster (ISSC)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2014, Una Bernadette Crowley. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Electrochemistry en
dc.subject Chemiluminescence en
dc.subject Toner-based microchips en
dc.subject Acetate microelectrode configuration en
dc.subject Modified screen-printed electrodes en
dc.subject Carbon monolith material en
dc.subject Metal nanoparticles en
dc.title Development of low-cost sensing and separation devices based on macro, micro and nano technology for health applications en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD (Science) en
dc.internal.availability Full text available en
dc.check.info No embargo required en
dc.description.version Accepted Version
dc.contributor.funder Science Foundation Ireland en
dc.description.status Not peer reviewed en
dc.internal.school Chemistry en
dc.internal.school Tyndall National Institute en
dc.check.type No Embargo Required
dc.check.reason No embargo required en
dc.check.opt-out No en
dc.thesis.opt-out false
dc.check.embargoformat Not applicable en
ucc.workflow.supervisor eric.moore@tyndall.ie
dc.internal.conferring Spring Conferring 2015


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© 2014, Una Bernadette Crowley. Except where otherwise noted, this item's license is described as © 2014, Una Bernadette Crowley.
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