LC3B globular structures correlate with survival in esophageal adenocarcinoma

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dc.contributor.author El-Mashad, Shereen M.
dc.contributor.author O'Donovan, Tracey R.
dc.contributor.author Kay, Elaine W.
dc.contributor.author Abdallah, Ayat R.
dc.contributor.author Cathcart, Mary-Clare
dc.contributor.author O'Sullivan, Jacintha
dc.contributor.author O'Grady, Anthony
dc.contributor.author Reynolds, John
dc.contributor.author O'Reilly, Seamus
dc.contributor.author O'Sullivan, Gerald C.
dc.contributor.author McKenna, Sharon L.
dc.date.accessioned 2016-01-14T16:40:07Z
dc.date.available 2016-01-14T16:40:07Z
dc.date.issued 2015-08-12
dc.identifier.citation EL-MASHED, S., O’DONOVAN, T. R., KAY, E. W., ABDALLAH, A. R., CATHCART, M.-C., O’SULLIVAN, J., O’GRADY, A., REYNOLDS, J., O’REILLY, S., O’SULLIVAN, G. C. & MCKENNA, S. L. 2015. LC3B globular structures correlate with survival in esophageal adenocarcinoma. BMC Cancer, 15:582, 1-12. http://dx.doi.org/10.1186/s12885-015-1574-5 en
dc.identifier.volume 15 en
dc.identifier.startpage 1 en
dc.identifier.endpage 12 en
dc.identifier.issn 1471-2407
dc.identifier.uri http://hdl.handle.net/10468/2185
dc.identifier.doi 10.1186/s12885-015-1574-5
dc.description.abstract Background: Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome. Methods: Esophageal adenocarcinoma tumor tissue from two independent sites, was examined retrospectively. Tumors from 104 neoadjuvant naïve patients and 48 patients post neoadjuvant therapy were assembled into tissue microarrays prior to immunohistochemical analysis. Kaplan-Meier survival curves and log-rank tests were used to assess impact of LC3B expression on survival. Cox regression was used to examine association with clinical risk factors. Results: A distinct globular pattern of LC3B expression was found to be predictive of outcome in both patient groups, irrespective of treatment (p < 0.001). Multivariate analysis found that this was a strong independent predictor of poor prognosis (p < 0.001). Conclusions: This distinctive staining pattern of LC3B represents a novel prognostic marker for resectable esophageal adenocarcinoma. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Biomed Central Ltd. en
dc.rights © 2015 El-Mashed et al.; licensee BioMed Central Ltd. 2015. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Stone like structures en
dc.subject Light chain 3b en
dc.subject Cancer cells en
dc.subject Prognostic relevance en
dc.subject Markers beclin-1 en
dc.subject Breast-cancer en
dc.subject Autophagy en
dc.subject Carcinomas en
dc.subject LC3B protein en
dc.subject Cell viability en
dc.subject Lymph node metastasis en
dc.subject Lymph vessel metastasis en
dc.subject Major clinical study en
dc.subject Overall survival en
dc.subject Perineural invasion en
dc.subject Retrospective study en
dc.subject Survival time en
dc.subject Treatment outcome en
dc.subject Tumor differentiation en
dc.subject Microtubule associated protein en
dc.subject Antibody specificity en
dc.subject Cancer adjuvant therapy en
dc.subject Cancer survival en
dc.subject Esophageal adenocarcinoma en
dc.title LC3B globular structures correlate with survival in esophageal adenocarcinoma en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Sharon L. McKenna. Biochemistry, Cork Cancer Research Centre, University College Cork, Cork, Ireland. +353-21-490-5710 Email: s.mckenna@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Higher Education Authority en
dc.contributor.funder Breakthrough Cancer Research, Ireland en
dc.contributor.funder Egyptian Education Bureau en
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMC Cancer en
dc.internal.copyrightchecked Open Access articles licensed via CC-BY 4.0 with UCC affiliated authors. Uploaded Jan 2016. en
dc.identifier.articleid 582


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© 2015 El-Mashed et al.; licensee BioMed Central Ltd. 2015. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Except where otherwise noted, this item's license is described as © 2015 El-Mashed et al.; licensee BioMed Central Ltd. 2015. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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