Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme

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dc.contributor.author Stack, Austin G.
dc.contributor.author Casserly, Liam F.
dc.contributor.author Cronin, Cornelius J.
dc.contributor.author Chernenko, Tetyana
dc.contributor.author Cullen, Walter
dc.contributor.author Hannigan, Ailish
dc.contributor.author Saran, Rajiv
dc.contributor.author Johnson, Howard
dc.contributor.author Browne, Gemma
dc.contributor.author Ferguson, John P.
dc.date.accessioned 2016-01-20T10:42:52Z
dc.date.available 2016-01-20T10:42:52Z
dc.date.issued 2014-11-25
dc.identifier.citation STACK, A. G., CASSERLY, L. F., CRONIN, C. J., CHERNENKO, T., CULLEN, W., HANNIGAN, A., SARAN, R., JOHNSON, H., BROWNE, G. & FERGUSON, J. P. 2014. Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme. BMC Nephrology, 15:185, 1-12. http://dx.doi.org/10.1186/1471-2369-15-185 en
dc.identifier.volume 15 en
dc.identifier.startpage 1 en
dc.identifier.endpage 12 en
dc.identifier.issn 1471-2369
dc.identifier.uri http://hdl.handle.net/10468/2199
dc.identifier.doi 10.1186/1471-2369-15-185
dc.description.abstract BACKGROUND: Chronic Kidney Disease (CKD) is a major non-communicable chronic disease that is associated with adverse clinical and economic outcomes. Passive surveillance systems are likely to improve efforts for prevention of chronic kidney disease (CKD) and inform national service planning. This study was conducted to determine the overall prevalence of CKD in the Irish health system, assess period trends and explore patterns of variation as part of a novel surveillance initiative. METHODS: We identified 207, 336 adult patients, age 18 and over, with serum creatinine measurements recorded from a provincial database between 2005-2011 in the Northwest of Ireland. Estimated glomerular filtration rates (eGFR) were determined using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation from standardized creatinine measurements and the presence of CKD was defined as eGFR <60 ml/min per 1.73 m2. Age and sex-specific prevalence estimates were determined for each group while generalized estimating equations (GEE) and multivariable logistic regression were used to explore associations using adjusted odds ratios (AOR) and 95% confidence intervals (95% CI). RESULTS: The prevalence of CKD in the health system was 11.8% (95% CI 11.8-12.1); 10.9% in men (10.7-11.1) and 12.6% in women (12.4-12.8). This corresponded to a detection rate of 4.5% (5.1% in women and 3.9% in men). The prevalence of CKD was significantly higher in women than in men (12.6% versus 10.9%, P < 0.001), older age groups, and among patients with a history of Acute Kidney Injury (AKI) than without (45.2% versus 10.7%, P < 0.0001). Multivariable analysis identified advancing age, female gender, location of medical supervision, county of residence, and AKI as significant determinants of prevalence. CONCLUSION: The prevalence of CKD in the Irish health system is 11.8% corresponding to a detection rate of 4.5% in the general population. Demographic, geographic factors and acute kidney injury episodes are important determinants of disease burden. Passive surveillance of CKD is both feasible and desirable within the Irish health system, and offers huge opportunities for targeted prevention programmes and improved clinical outcomes en
dc.description.sponsorship Health Research Board (HRA-2013-PHR-437); Medical Education Liaison Group (MELG) University Hospital Limerick. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Biomed Central Ltd. en
dc.rights © 2014 Stack et al.; licensee BioMed Central Ltd., 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject CKD surveillance en
dc.subject Health system en
dc.subject Epidemiology en
dc.subject Risk factors en
dc.subject Glomerular filtration rate en
dc.subject Serum creatinine en
dc.subject Acute kidney failure en
dc.subject Chronic kidney disease en
dc.subject Creatinine blood level en
dc.subject Disease surveillance en
dc.subject Health care system en
dc.subject Irish citizen en
dc.subject Renal system en
dc.subject Sex difference en
dc.subject Male en
dc.subject Female en
dc.subject Comparative study en
dc.subject Controlled study en
dc.subject Retrospective study en
dc.subject Major clinical study en
dc.subject Glomerulus filtration rate en
dc.title Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gemma Browne, Epidemiology & Public Health, University College Cork, Cork, Ireland. +353-21-420-5505 Email: g.browne@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Health Research Board en
dc.contributor.funder University Hospital Limerick en
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMC Nephrology en
dc.internal.copyrightchecked Open Access articles licensed via CC-BY 4.0 with UCC affiliated authors. Uploaded Jan 2016. en
dc.internal.IRISemailaddress g.browne@ucc.ie en
dc.identifier.articleid 185


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© 2014 Stack et al.; licensee BioMed Central Ltd., 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Except where otherwise noted, this item's license is described as © 2014 Stack et al.; licensee BioMed Central Ltd., 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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