Risk factors and birth outcomes of anaemia in early pregnancy in a nulliparous cohort

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dc.contributor.author Masukume, Gwinyai
dc.contributor.author Khashan, Ali S.
dc.contributor.author Kenny, Louise C.
dc.contributor.author Baker, Philip N.
dc.contributor.author Nelson, Gill
dc.date.accessioned 2016-02-17T10:07:58Z
dc.date.available 2016-02-17T10:07:58Z
dc.date.issued 2015
dc.identifier.citation Masukume G, Khashan AS, Kenny LC, Baker PN, Nelson G, SCOPE Consortium (2015) Risk Factors and Birth Outcomes of Anaemia in Early Pregnancy in a Nulliparous Cohort. PLoS ONE 10(4): e0122729. doi:10.1371/journal.pone.0122729
dc.identifier.volume 10 en
dc.identifier.issued 4 en
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10468/2309
dc.identifier.doi 10.1371/journal.pone.0122729
dc.description.abstract Background: Anaemia in pregnancy is a major public health and economic problem worldwide, that contributes to both maternal and fetal morbidity and mortality. Objective: The aim of the study was to calculate the prevalence of anaemia in early pregnancy in a cohort of 'low risk' women participating in a large international multicentre prospective study (n = 5 609), to identify the modifiable risk factors for anaemia in pregnancy in this cohort, and to compare the birth outcomes between pregnancies with and without anaemia in early gestation. Methods: The study is an analysis of data that were collected prospectively during the Screening for Pregnancy Endpoints study. Anaemia was defined according to the World Health Organization's definition of anaemia in pregnancy (haemoglobin <11g/dL). Binary logistic regression with adjustment for potential confounders (country, maternal age, having a marital partner, ethnic origin, years of schooling, and having paid work) was the main method of analysis. Results: The hallmark findings were the low prevalence of anaemia (2.2%), that having no marital partner was an independent risk factor for having anaemia (OR 1.34, 95% CI 1.01-1.78), and that there was no statistically significant effect of anaemia on adverse pregnancy outcomes (small for gestational age, pre-tem birth, mode of delivery, low birth weight, APGAR score < 7 at one and five minutes). Adverse pregnancy outcomes were however more common in those with anaemia than in those without. Conclusion: In this low risk healthy pregnant population we found a low anaemia rate. The absence of a marital partner was a non-modifiable factor, albeit one which may reflect a variety of confounding factors, that should be considered for addition to anaemia's conceptual framework of determinants. Although not statistically significant, clinically, a trend towards a higher risk of adverse pregnancy outcomes was observed in women that were anaemic in early pregnancy. en
dc.description.sponsorship RMIT University, Australia (New Enterprise Research Fund); Health Research Council, New Zealand (04/198); Government of South Australia (Premier's Science and Research Fund); Biotechnology and Biological Sciences Research Council, United Kingdom (GT084); National Health Service, United Kingdom (NEAT FSD025); University of Manchester (Proof of Concept Funding); Health Research Board, Ireland (CSA/2007/2) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Public Library of Science en
dc.rights © 2015 Masukume et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Iron deficiency en
dc.subject Maternal anemia en
dc.subject Delivery en
dc.subject Smoking en
dc.subject Disease en
dc.subject Women en
dc.title Risk factors and birth outcomes of anaemia in early pregnancy in a nulliparous cohort en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Louise Kenny, Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: l.kenny@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.rssid 340371328
dc.internal.wokid WOS:000353015800074
dc.contributor.funder RMIT University, Australia
dc.contributor.funder Foundation for Research, Science and Technology, New Zealand
dc.contributor.funder Health Research Council, New Zealand
dc.contributor.funder Evelyn Bond Fund, New Zealand
dc.contributor.funder Auckland District Health Board Charitable Trust, New Zealand
dc.contributor.funder Government of South Australia
dc.contributor.funder Guy's and St Thomas' Charity
dc.contributor.funder Tommy's Baby Charity
dc.contributor.funder Biotechnology and Biological Sciences Research Council
dc.contributor.funder National Health Service, United Kingdom
dc.contributor.funder University of Manchester, United Kingdom
dc.contributor.funder National Institute for Health Research, United Kingdom
dc.contributor.funder Cerebra, United Kingdom
dc.contributor.funder Health Research Board
dc.description.status Peer reviewed en
dc.identifier.journaltitle PLOS ONE en
dc.internal.IRISemailaddress l.kenny@ucc.ie en
dc.identifier.articleid e0122729


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© 2015 Masukume et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Except where otherwise noted, this item's license is described as © 2015 Masukume et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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