Hysteresis can grant fitness in stochastically varying environment

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dc.contributor.author Friedman, Gary
dc.contributor.author McCarthy, Stephen P.
dc.contributor.author Rachinskii, Dmitrii
dc.date.accessioned 2016-02-17T11:43:39Z
dc.date.available 2016-02-17T11:43:39Z
dc.date.issued 2014
dc.identifier.citation Friedman G, McCarthy S, Rachinskii D (2014) Hysteresis Can Grant Fitness in Stochastically Varying Environment. PLoS ONE 9(7): e103241. doi:10.1371/journal.pone.0103241
dc.identifier.volume 9 en
dc.identifier.issued 7 en
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10468/2328
dc.identifier.doi 10.1371/journal.pone.0103241
dc.description.abstract Although the existence of multiple stable phenotypes of living organisms enables random switching between phenotypes as well as non-random history dependent switching called hysteresis, only random switching has been considered in prior experimental and theoretical models of adaptation to variable environments. This work considers the possibility that hysteresis may also evolve together with random phenotype switching to maximize population growth. In addition to allowing the possibility that switching rates between different phenotypes may depend not only on a continuous environmental input variable, but also on the phenotype itself, the present work considers an opportunity cost of the switching events. This opportunity cost arises as a result of a lag phase experimentally observed after phenotype switching and stochastic behavior of the environmental input. It is shown that stochastic environmental variation results in maximal asymptotic growth rate when organisms display hysteresis for sufficiently slowly varying environmental input. At the same time, sinusoidal input does not cause evolution of memory suggesting that the connection between the lag phase, stochastic environmental variation and evolution of hysteresis is a result of a stochastic resonance type phenomenon. en
dc.description.sponsorship Russian Foundation for Basic Research (Grant No. 10-01-93112) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Public Library of Science en
dc.rights © 2015 Friedman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Galactoside-enzyme system en
dc.subject Escherichia coli en
dc.subject Gene expression en
dc.subject Fluctuating environments en
dc.subject Bacillus subtilis en
dc.subject Switch en
dc.subject Cell en
dc.subject Transitions en
dc.subject Memory en
dc.subject Differentiation en
dc.title Hysteresis can grant fitness in stochastically varying environment en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Dmitrii Rachinskii, School of Mathematical Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: D.Rachinskii@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.wokid WOS:000339993700050
dc.contributor.funder Russian Foundation for Basic Research
dc.contributor.funder Alexander von Humboldt-Stiftung
dc.description.status Peer reviewed en
dc.identifier.journaltitle PLOS ONE en
dc.internal.IRISemailaddress d.rachinskii@ucc.ie en
dc.identifier.articleid e103241


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© 2015 Friedman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Except where otherwise noted, this item's license is described as © 2015 Friedman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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