Hysteresis can grant fitness in stochastically varying environment
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Published Version
Date
2014
Authors
Friedman, Gary
McCarthy, Stephen P.
Rachinskii, Dmitrii
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Published Version
Abstract
Although the existence of multiple stable phenotypes of living organisms enables random switching between phenotypes as well as non-random history dependent switching called hysteresis, only random switching has been considered in prior experimental and theoretical models of adaptation to variable environments. This work considers the possibility that hysteresis may also evolve together with random phenotype switching to maximize population growth. In addition to allowing the possibility that switching rates between different phenotypes may depend not only on a continuous environmental input variable, but also on the phenotype itself, the present work considers an opportunity cost of the switching events. This opportunity cost arises as a result of a lag phase experimentally observed after phenotype switching and stochastic behavior of the environmental input. It is shown that stochastic environmental variation results in maximal asymptotic growth rate when organisms display hysteresis for sufficiently slowly varying environmental input. At the same time, sinusoidal input does not cause evolution of memory suggesting that the connection between the lag phase, stochastic environmental variation and evolution of hysteresis is a result of a stochastic resonance type phenomenon.
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Keywords
Galactoside-enzyme system , Escherichia coli , Gene expression , Fluctuating environments , Bacillus subtilis , Switch , Cell , Transitions , Memory , Differentiation
Citation
Friedman G, McCarthy S, Rachinskii D (2014) Hysteresis Can Grant Fitness in Stochastically Varying Environment. PLoS ONE 9(7): e103241. doi:10.1371/journal.pone.0103241