Identifying early inflammatory changes in monocyte derived macrophages from a population with IQ discrepant episodic memory

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dc.contributor.author Downer, Eric J.
dc.contributor.author Jones, Raasay S.
dc.contributor.author McDonald, Claire L.
dc.contributor.author Greco, Eleonora
dc.contributor.author Brennan, Sabina
dc.contributor.author Connor, Thomas J.
dc.contributor.author Robertson, Ian H.
dc.contributor.author Lynch, Marina A.
dc.date.accessioned 2016-02-17T11:46:18Z
dc.date.available 2016-02-17T11:46:18Z
dc.date.issued 2013
dc.identifier.citation Downer EJ, Jones RS, McDonald CL, Greco E, Brennan S, Connor TJ, et al. (2013) Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory. PLoS ONE 8(5): e63194. doi:10.1371/journal.pone.0063194 en
dc.identifier.volume 8 en
dc.identifier.issued 5 en
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10468/2380
dc.identifier.doi 10.1371/journal.pone.0063194
dc.description.abstract Background: Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like receptors (TLRs), innate immune receptors which govern tailored inflammatory gene expression patterns. Monocytes, which produce pro-inflammatory mediators, are readily recruited to the central nervous system (CNS) in neurodegenerative diseases. Methods: This study explored the expression of receptors (CD11b, TLR2 and TLR4) on circulating monocyte-derived macrophages (MDMs) and peripheral blood mononuclear cells (PBMCs) isolated from healthy elderly adults who we classified as either IQ memory-consistent (high-performing, HP) or IQ memory-discrepant (low-performing, LP). Results: The expression of CD11b, TLR4 and TLR2 was increased in MDMs from the LP group when compared to HP cohort. MDMs from both groups responded robustly to treatment with the TLR4 activator, lipopolysaccharide (LPS), in terms of cytokine production. Significantly, MDMs from the LP group displayed hypersensitivity to LPS exposure. Interpretation: Overall these findings define differential receptor expression and cytokine profiles that occur in MDMs derived from a cohort of IQ memory-discrepant individuals. These changes are indicative of inflammation and may be involved in the prodromal processes leading to the development of neurodegenerative disease. en
dc.description.sponsorship Science Foundation Ireland (SFI Grant no.07/IN.1/B949); Health Research Board; Trinity College Dublin (Institute of Neuroscience Research Consortium on Neurodegeneration); Atlantic Philanthropies (Neuroenhancement for Independence in Elder Lives (NIEL)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Public Library of Science en
dc.rights @ 2013 Downer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Central nervous system en
dc.subject Mild cognitive impairment en
dc.subject Blood mononuclear cells en
dc.subject Amyloid beta protein en
dc.subject Alzheimers disease en
dc.subject Immune system en
dc.subject Microglial activation en
dc.subject Signal transduction en
dc.subject Cytokine production en
dc.subject Dendritic cells en
dc.title Identifying early inflammatory changes in monocyte derived macrophages from a population with IQ discrepant episodic memory en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Eric J. Downer, Anatomy and Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: edowner@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.wokid WOS:000321390200046
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Atlantic Philanthropies en
dc.contributor.funder Trinity College Dublin en
dc.description.status Peer reviewed en
dc.identifier.journaltitle PLOS ONE en
dc.internal.IRISemailaddress edowner@ucc.ie en
dc.identifier.articleid e63194


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@ 2013 Downer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Except where otherwise noted, this item's license is described as @ 2013 Downer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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