Citation:O'SULLIVAN, T. P., ZHANG, H. & MANDER, L. N. 2007. Model studies toward the synthesis of the bioactive diterpenoid, harringtonolide. Organic & Biomolecular Chemistry, 5, 2627-2635. http://dx.doi.org/10.1039/B707467K
In model studies towards the synthesis of harringtonolide, the construction of the tropone moiety via arene cyclopropanation was investigated. The installation of the lactone ring was accomplished by way of a Diels-Alder cycloaddition of various indenones and 𝛼-pyones. The incorporation of the key bridge methyl group and subsequent control of its stereochemistry is also outlined.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement