• Is there potential for repurposing statins as novel antimicrobials? 

  Hennessy, Emma; Adams, Claire; Reen, F. Jerry; O'Gara, Fergal (American Society for Microbiology, 2016-08-22)

  Statins are members of a class of pharmaceutical widely used to reduce high levels of serum cholesterol. In addition, statins have so-called "pleiotropic effects," which include inflammation reduction, immunomodulation, ...
• Evidence for plasmid-mediated salt tolerance in the human gut microbiome and potential mechanisms 

  Broaders, Eileen; O'Brien, Ciarán; Gahan, Cormac G. M.; Marchesi, Julian R. (Oxford University Press, 2016-02-04)

  The human gut microbiome is critical to health and wellbeing. It hosts a complex ecosystem comprising a multitude of bacterial species, which contributes functionality that would otherwise be absent from the host. Transient ...
• Regulation of prefrontal cortex myelination by the microbiota 

  Hoban, Alan E.; Stilling, Roman M.; Ryan, Feargal J.; Shanahan, Fergus; Dinan, Ted G.; Claesson, Marcus J.; Clarke, Gerard; Cryan, John F. (Nature Publishing Group, 2016-04-05)

  The prefrontal cortex (PFC) is a key region implicated in a range of neuropsychiatric disorders such as depression, schizophrenia and autism. In parallel, the role of the gut microbiota in contributing to these disorders ...
• Role of the Photorhabdus Dam methyltransferase during interactions with its invertebrate hosts 

  Payelleville, Amaury; Blackburn, Dana; Lanois, Anne; Pagès, Sylvie; Cambon, Marine C.; Ginibre, Nadege; Clarke, David J.; Givaudan, Alain; Brillard, Julien (Public Library of Science, 2019-10-09)

  Photorhabdus luminescens is an entomopathogenic bacterium found in symbiosis with the nematode Heterorhabditis. Dam DNA methylation is involved in the pathogenicity of many bacteria, including P. luminescens, whereas studies ...
• Dissecting the regulation of bile-induced biofilm formation in Staphylococcus aureus 

  Ulluwishewa, Dulantha; Wang, Liang; Pereira, Callen; Flynn, Stephanie; Cain, Elizabeth; Stick, Stephen; Reen, F. Jerry; Ramsay, Joshua P.; O'Gara, Fergal (Microbiology Society, 2016-08-01)

  Aspiration of bile into the cystic fibrosis (CF) lung has emerged as a prognostic factor for reduced microbial lung biodiversity and the establishment of often fatal, chronic pathogen infections. Staphylococcus aureus is ...

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