• An investigation into novel bacteriocin producers isolated for shelf life extension of dairy products 

  Sugrue, Ivan (University College Cork, 2020-07-27)

  This thesis investigates extension of the shelf life of dairy products and outlines the discovery and characterization of novel antimicrobials for application in food and health. The results demonstrate factors which affect ...
• Host genetics and epigenomics of inflammatory bowel disease 

  Power, E. M. (University College Cork, 2019-09-30)

  The overall aim of this thesis was to investigate the interaction between host-genetics and epigenetic profiles in IBD, particularly in CD. This included identifying epigenetic markers in CD patients with frequent relapses ...
• Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer 

  Keane, Jonathan M.; Joyce, Susan A.; Gahan, Cormac G. M.; Hyland, Niall P.; Houston, Aileen (Springer Nature Switzerland AG, 2020-12-03)

  The symbiosis between the gut microbiota and the host has been identified as an integral part of normal human physiology and physiological development. Research in germ-free or gnotobiotic animals has demonstrated the ...
• Structure-activity relationships of furanones, dihydropyrrolones and thiophenones as potential quorum sensing inhibitors 

  Lyons, Thérèse; Gahan, Cormac G. M.; O'Sullivan, Timothy P. (Newlands Press, 2020-10-23)

  Since their initial isolation from the marine alga Delisea pulchra, bromofuranones have been investigated as potential inhibitors of quorum sensing (QS) in various bacterial strains. QS is an important mechanism by which ...
• Gut microbiota composition correlates with diet and health in the elderly 

  Claesson, Marcus J.; Jeffery, Ian B.; Conde, Susana; Power, Susan E.; O'Connor, Eibhlí­s M.; Cusack, Siobhán; Harris, Hugh M. B.; Coakley, Mairead; Lakshminarayanan, Bhuvaneswari; O'Sullivan, Orla; Fitzgerald, Gerald F.; Deane, Jennifer; O'Connor, Michael; Harnedy, Norma; O'Connor, Kieran; O'Mahony, Denis; van Sinderen, Douwe; Wallace, Martina; Brennan, Lorraine; Stanton, Catherine; Marchesi, Julian R.; Fitzgerald, Anthony P.; Shanahan, Fergus; Hill, Colin; Ross, R. Paul; O'Toole, Paul W. (Macmillan Publishers Limited, 2012-07-13)

  Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than ...

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