An electro-responsive hydrogel for intravascular applications: an in vitro and in vivo evaluation

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dc.contributor.author Verbrugghe, Peter
dc.contributor.author Verhoeven, Jelle
dc.contributor.author Coudyzer, Walter
dc.contributor.author Verbeken, Eric
dc.contributor.author Dubruel, Peter
dc.contributor.author Mendes, Eduardo
dc.contributor.author Stam, Frank
dc.contributor.author Meuris, Bart
dc.contributor.author Herijgers, Paul
dc.date.accessioned 2016-05-16T14:52:16Z
dc.date.available 2016-05-16T14:52:16Z
dc.date.issued 2015-10-16
dc.identifier.citation Verbrugghe, P., Verhoeven, J., Coudyzer, W., Verbeken, E., Dubruel, P., Mendes, E., Stam, F., Meuris, B. & Herijgers, P. 2015. An electro-responsive hydrogel for intravascular applications: an in vitro and in vivo evaluation. Journal of Materials Science: Materials in Medicine, 26, 1-8. http://dx.doi.org/10.1007/s10856-015-5598-9 en
dc.identifier.volume 26 en
dc.identifier.issued 11 en
dc.identifier.startpage 264 (1) en
dc.identifier.endpage 264 (8) en
dc.identifier.uri http://hdl.handle.net/10468/2581
dc.identifier.doi 10.1007/s10856-015-5598-9
dc.description.abstract There is a growing interest in using hydrogels for biomedical applications, because of more favourable characteristics. Some of these hydrogels can be activated by using particular stimuli, for example electrical fields. These stimuli can change the hydrogel shape in a predefined way. It could make them capable of adaptation to patient-specific anatomy even post-implantation. This is the first paper aiming to describe in vivo studies of an electro-responsive, Pluronic F127 based hydrogel, for intravascular applications. Pluronic methacrylic acid hydrogel (PF127/MANa) was in vitro tested for its haemolytic and cytotoxic effects. Minimal invasive implantation in the carotid artery of sheep was used to evaluate its medium-term biological effects, through biochemical, macroscopic, radiographic, and microscopic evaluation. Indirect and direct testing of the material gave no indication of the haemolytic effects of the material. Determination of fibroblast viability after 24 h of incubation in an extract of the hydrogel showed no cytotoxic effects. Occlusion was obtained within 1 h following in vivo implantation. Evaluation at time of autopsy showed a persistent occlusion with no systemic effects, no signs of embolization and mild effects on the arterial wall. An important proof-of-concept was obtained showing biocompatibility and effectiveness of a pluronic based electro-responsive hydrogel for obtaining an arterial occlusion with limited biological impact. So the selected pluronic-methacrylic acid based hydrogel can be used as an endovascular occlusion device. More importantly it is the first step in further development of electro-active hydrogels for a broad range of intra-vascular applications (e.g. system to prevent endoleakage in aortic aneurysm treatment, intra-vascular drug delivery). en
dc.description.sponsorship European Commission ( EU Seventh Framework Program FP7/2007–2013 under Grant Agreement No. 258909.) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer en
dc.relation.uri http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608972/
dc.rights © The Authors 2015. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creative commons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Hydrogels en
dc.subject Pluronic methacrylic acid hydrogel en
dc.subject Occlusion device en
dc.subject Biomedical applications en
dc.subject Intra-vascular applications en
dc.title An electro-responsive hydrogel for intravascular applications: an in vitro and in vivo evaluation en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Frank Stam, Tyndall Microsystems, University College Cork, Cork, Ireland. +353-21-490-3000 Email: frank.stam@tyndall.ie en
dc.internal.availability Full text available en
dc.date.updated 2016-05-12T19:42:45Z
dc.description.version Published Version en
dc.internal.rssid 347879711
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal Of Materials Science en
dc.internal.copyrightchecked Yes !!CORA!! Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress frank.stam@tyndall.ie en


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© The Authors 2015. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creative commons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Except where otherwise noted, this item's license is described as © The Authors 2015. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creative commons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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