A cardiovascular occlusion method based on the use of a smart hydrogel

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dc.contributor.author Jackson, Nathan
dc.contributor.author Verbrugghe, Peter
dc.contributor.author Cuypers, D.
dc.contributor.author Adesanya, K.
dc.contributor.author Engel, L.
dc.contributor.author Glazer, P.
dc.contributor.author Dubruel, Peter
dc.contributor.author Mendes, Eduardo
dc.contributor.author Herijigers, P.
dc.contributor.author Stam, Frank
dc.date.accessioned 2016-06-10T08:51:09Z
dc.date.available 2016-06-10T08:51:09Z
dc.date.issued 2014-09-04
dc.identifier.citation Jackson, N., Verbrugghe, P., Cuypers, D., Adesanya, K., Engel, L., Glazer, P., Dubruel, P., Mendes, E., Herijigers, P. and Stam, F. (2014) 'A cardiovascular occlusion method based on the use of smart hydrogels', IEEE Transactions On Biomedical Engineering, 62(2), pp. 399-406. doi: 10.1109/TBME.2014.2353933 en
dc.identifier.volume 62 en
dc.identifier.issued 2 en
dc.identifier.startpage 399 en
dc.identifier.endpage 406 en
dc.identifier.issn 0018-9294
dc.identifier.uri http://hdl.handle.net/10468/2715
dc.identifier.doi 10.1109/TBME.2014.2353933
dc.description.abstract Smart hydrogels for biomedical applications are highly researched materials. However, integrating them into a device for implantation is difficult. This paper investigates an integrated delivery device designed to deliver an electro-responsive hydrogel to a target location inside a blood vessel with the purpose of creating an occlusion. The paper describes the synthesis and characterization of a Pluronic/methacrylic acid sodium salt electro-responsive hydrogel. Application of an electrical bias decelerates the expansion of the hydrogel. An integrated delivery system was manufactured to deliver the hydrogel to the target location in the body. Ex vivo and in vivo experiments in the carotid artery of sheep were used to validate the concept. The hydrogel was able to completely occlude the blood vessel reducing the blood flow from 245 to 0 ml/min after implantation. Ex vivo experiments showed that the hydrogel was able to withstand physiological blood pressures of > 270 mm·Hg without dislodgement. The results showed that the electro-responsive hydrogel used in this paper can be used to create a long-term occlusion in a blood vessel without any apparent side effects. The delivery system developed is a promising device for the delivery of electro-responsive hydrogels. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher IEEE en
dc.rights © 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. en
dc.subject Blood vessel en
dc.subject Cardiovascular en
dc.subject Delivery device en
dc.subject Electroactivation en
dc.subject Hydrogel en
dc.subject Occlusion en
dc.title A cardiovascular occlusion method based on the use of a smart hydrogel en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Frank Stam, Tyndall Microsystems, University College Cork, Cork, Ireland. +353-21-490-3000 Email: frank.stam@tyndall.ie en
dc.internal.availability Full text available en
dc.date.updated 2015-01-20T12:14:30Z
dc.description.version Accepted Version en
dc.internal.rssid 273393648
dc.description.status Peer reviewed en
dc.identifier.journaltitle IEEE Transactions on Biomedical Engineering en
dc.internal.copyrightchecked No. !!CORA!! Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress frank.stam@tyndall.ie en


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