Chitosan gel film bandages: correlating structure, composition, and antimicrobial properties

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dc.contributor.author Anaya, P.
dc.contributor.author Cárdenas, G.
dc.contributor.author Lavayen, Vladimir
dc.contributor.author García, A.
dc.contributor.author O'Dwyer, Colm
dc.date.accessioned 2016-06-29T11:38:47Z
dc.date.available 2016-06-29T11:38:47Z
dc.date.issued 2012-10-16
dc.identifier.citation Anaya, P., Cárdenas, G., Lavayen, V., García, A. & O'Dwyer, C. (2013) ‘Chitosan gel film bandages: correlating structure, composition, and antimicrobial properties’, Journal of Applied Polymer Science, 128(6), pp. 3939-3948. http://dx.doi.org/10.1002/app.38621 en
dc.identifier.volume 128 en
dc.identifier.issued 6 en
dc.identifier.startpage 3939 en
dc.identifier.endpage 3948 en
dc.identifier.issn 0021-8995
dc.identifier.uri http://hdl.handle.net/10468/2810
dc.identifier.doi 10.1002/app.38621
dc.description.abstract Chitosan gel films were successfully obtained by evaporation cast from chitosan solutions in aqueous acidic solutions of organic acids (lactic and acetic acid) as gel film bandages, with a range of additives that directly influence film morphology and porosity. We show that the structure and composition of a wide range of 128 thin gel films, is correlated to the antimicrobial properties, their biocompatibility and resistance to biodegradation. Infrared spectroscopy and solid-state 13C nuclear magnetic resonance spectroscopy was used to correlate film molecular structure and composition to good antimicrobial properties against 10 of the most prevalent Gram positive and Gram negative bacteria. Chitosan gel films reduce the number of colonies after 24 h of incubation by factors of ∼105–107 CFU/mL, compared with controls. For each of these films, the structure and preparation condition has a direct relationship to antimicrobial activity and effectiveness. These gel film bandages also show excellent stability against biodegradation with lysozyme under physiological conditions (5% weight loss over a period of 1 month, 2% in the first week), allowing use during the entire healing process. These chitosan thin films and subsequent derivatives hold potential as low-cost, dissolvable bandages, or second skin, with antimicrobial properties that prohibit the most relevant intrahospital bacteria that infest burn injuries. en
dc.description.sponsorship Innova Bio-Bio, Chile (Grant 03-B1-212-L1); Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil (CNPq, (400297/2010-8)); Fondo Nacional de Desarrollo Científico y Tecnológico, Chile (FONDECyT (1090683, 1090282)); Irish Government (INSPIRE Program, Program for Research in Third Level Institutions, Cycle 4, National Development Plan 2007-2013); Science Foundation Ireland (SFI contract no. 07/SK/B1232a.) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.rights © 2012 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Anaya, P eta al., ‘Chitosan gel film bandages: correlating structure, composition, and antimicrobial properties’, Journal of Applied Polymer Science, 128, pp. 3939-3948 which has been published in final form at http://dx.doi.org/10.1002/app.38621. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Biodegradable en
dc.subject Biomedical applications en
dc.subject Biopolymers and renewable polymers en
dc.subject Gels en
dc.subject Biocompatibility en
dc.title Chitosan gel film bandages: correlating structure, composition, and antimicrobial properties en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Colm O'Dwyer, Chemistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: c.odwyer@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2012-11-29T17:23:43Z
dc.description.version Accepted Version en
dc.internal.rssid 162343195
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Applied Polymer Science en
dc.internal.copyrightchecked No. !!CORA!! Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress c.odwyer@ucc.ie en


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