Tooth wear in Irish teenagers: a laboratory and epidemiological study

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dc.contributor.advisor Whelton, Helen en
dc.contributor.advisor Sheehan, David en Harding, Máiréad 2016-06-29T14:51:41Z 2016-06-29T14:51:41Z 2015 2015
dc.identifier.citation Harding, M. A. 2015. Tooth wear in Irish teenagers: a laboratory and epidemiological study. PhD Thesis, University College Cork. en
dc.description.abstract Aim: To investigate the characteristics, development and determinants of toothwear among Irish schoolchildren. Methods: A cross-sectional (examination at 16-years-old) and longitudinal (examinations at 5-,12-,14-years) study were conducted. Two indices were used to measure toothwear, children/parents completed a demographic profile and questionnaire on oral hygiene and dietary practices, health, and lifestyle in both studies. Saliva was collected from consenting 16-year-olds. The explanatory variables for the cross-sectional and longitudinal study were derived from children/parents responses. Differences in salivary profiles were determined for subsets; the protein concentration was determined with Bradford protein assay and protein carbonyl concentration (a protein oxidation marker) was determined spectrophotometrically. Gel-electrophoresis and mass spectrometry determined proteins and ion chromatography inorganic ions. Statistical significance was accepted at p<0.05. Results: At 16-years-old the prevalence of toothwear with dentine visible was 44%. No difference in salivary flow rates existed. In unstimulated saliva a higher mean, protein carbonyl (p<0.0001) and total calcium concentration (p<0.002) existed for the group with moderate toothwear. In stimulated saliva the moderate toothwear group had a lower mean protein concentration(p<0.0001). The 2-DE protein spots prepared for a sub-group differed between those with toothwear and without. Mass spectrometry, identified one of the different proteins as IgA. For 16-year-olds, the self-reported factors indicated that brushing after breakfast was associated with lower toothwear scores(p<0.03). Nail-biting, being asthmatic or reporting a dry mouth were associated with higher toothwear scores(all p<0.05). Eating an apple daily or less was associated with less toothwear(p<0.002). In the longitudinal study toothwear into dentine at age five or 12-years was associated with more toothwear at age 14(all p<0.05). Discussion: The results illustrate the multifactorial aetiology of toothwear. The biochemical and physical correlates of saliva with toothwear requires further research. Conclusion: The impact of previous toothwear, salivary, dietary and personal factors on toothwear in the early permanent dentition is demonstrated. en
dc.description.sponsorship Health Research Board (HRB Project grant PR/2005/267) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2015, Máiréad A. Harding en
dc.rights.uri en
dc.subject Epidemiological en
dc.subject Tooth wear en
dc.subject Diet en
dc.subject Index en
dc.subject Saliva en
dc.title Tooth wear in Irish teenagers: a laboratory and epidemiological study en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Dentistry) en
dc.internal.availability Full text available en No embargo required en
dc.description.version Accepted Version
dc.contributor.funder GSK Consumer Healthcare (UK) en
dc.contributor.funder Health Research Board en
dc.description.status Not peer reviewed en Oral Health & Development en
dc.check.type No Embargo Required
dc.check.reason No embargo required en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.embargoformat Not applicable en
dc.internal.conferring Autumn 2015 en

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© 2015, Máiréad A. Harding Except where otherwise noted, this item's license is described as © 2015, Máiréad A. Harding
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