• Major structure-activity relationships of resolvins, protectins, maresins and their analogues 

  Daly, Kevin; O'Sullivan, Killian; O'Sullivan, Timothy P. (Future Science Ltd, 2022-11-30)

  Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate ...
• Pharmaceutical salts of piroxicam and meloxicam with organic counterions 

  Huang, Shan; Venables, Dean S.; Lawrence, Simon E. (ACS Publications, 2022-10-21)

  Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs, belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six novel pharmaceutical salts of PRM and MEL with ...
• Synthesis and reactivity of dihalofuranones 

  Lyons, Thérèse A.; Gahan, Cormac G. M.; O'Sullivan, Timothy P. (Bentham Science Publishers, 2022-08-01)

  Halogenated furanones have been found to act as potent quorum sensing inhibitors in several bacterial species. It is believed that dihalofuranones covalently bind to the LuxS enzyme, which is necessary for autoinducer-2 ...
• Synthesis of novel quorum sensing inhibitors of DSF 

  Horgan, Conor (University College Cork, 2022)

  Antimicrobial resistance (AMR) has become a growing concern among the medical community with many previously effective antibiotics losing their efficacy. Much of this AMR is thought to stem from biofilm formation controlled ...
• Studies in derivatisation and direct arylation of heterocycles 

  Hickey, Aobha (University College Cork, 2022)

  Quorum sensing (QS) is a complex form of communication employed by bacterial species to coordinate group behaviours through the biosynthesis, secretion and detection of small molecules known as autoinducers (AIs). Understanding ...

View more