• Synthesis and antiproliferative activity of novel heterocyclic indole-trimethoxyphenyl conjugates 

  Cahill, Michael; O’Shea, Kevin; Pierce, Larry; Winfield, Hannah; Eccles, Kevin; Lawrence, Simon E.; McCarthy, Florence O. (MDPI, 2017)

  The synthesis and biological evaluation of a series of novel heterocyclic indole derivatives is described. The consolidation of the combretastatin and bisindolylmaleimide templates towards the inclusion of a novel heterocyclic ...
• Molecular signature of Pseudomonas aeruginosa with simultaneous nanomolar detection of quorum sensing signaling molecules at a Boron-Doped diamond electrode 

  Buzid, Alyah; Shang, Fengjun; Reen, F. Jerry; Ó Muimhneacháin, Eoin; Clarke, Sarah L.; Zhou, Lin; Luong, John H. T.; O'Gara, Fergal; McGlacken, Gerard P.; Glennon, Jeremy D. (Nature Publishing Group, 2016-07-18)

  Electroanalysis was performed using a boron-doped diamond (BDD) electrode for the simultaneous detection of 2-heptyl-3-hydroxy-4-quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and pyocyanin (PYO). PQS and its precursor ...
• The application of molecular tethers in controlling axial chirality 

  Reen, Michael; O'Sullivan, Timothy P. (Bentham Science Publishers, 2016-06)

  Atropisomeric biaryl compounds are an attractive target in organic chemistry due to their abundance in nature and their utility as ligands in catalysis. Among the methods available for their synthesis, the use of chiral ...
• Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics 

  Leary, Eileen M.; Jones, David J.; O'Donovan, Fiona P.; O'Sullivan, Timothy P. (Elsevier, 2015-06-11)

  Milk protein concentrate (79% protein) reconstituted at 13.5% (w/v) protein was heated (90 °C, 25 min, pH 7.2) with or without added calcium chloride. After fractionation of the casein and whey protein aggregates by fast ...
• Guanine a-carboxy nucleoside phosphonate (G-a-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses 

  Balzarini, Jan; Menni, Michael; Das, Kalyan; van Berckelaer, Lizette; Ford, Alan; Maguire, Nuala M.; Liekens, Sandra; Boehmer, Paul E.; Arnold, Eddy; Götte, Matthias; Maguire, Anita R. (Elsevier, 2017-04-06)

  α-Carboxy nucleoside phosphonates (α-CNPs) are modified nucleotides that represent a novel class of nucleotide-competing reverse transcriptase (RT) inhibitors (NcRTIs). They were designed to act directly against HIV-1 RT ...

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