• Programmed genetic decoding with an emphasis on translational bypassing 

  O'Loughlin, Sinéad (University College Cork, 2020-01)

  The process of gene expression was long believed to be fixed across all domains of life, set in stone by both the universality of the genetic code and the protein-synthesising machinery that decodes it. However, exceptions ...
• Localized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurity 

  Flynn, Aaran J.; Ford, Alan; Maguire, Anita R. (American Chemical Society, 2020-07-02)

  Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation ...
• Studies in asymmetric synthesis: I. the asymmetric α-alkylation of N,N-dimethylhydrazones II. the asymmetric aldol-Tishchenko reaction of (S)-tert-butanesulfinyl imines for the introduction of 2, 3, 4 and 5 new chiral centres in one pot 

  Mackey, Pamela (University College Cork, 2020-08-30)

  This thesis is split into two sections based on two different areas of research. Part 1 The asymmetric α-alkylation of ketones is one of the most fundamental yet challenging transformations in organic chemistry. Recently ...
• The crystal landscape and cocrystallization of primary aromatic sulfonamides 

  Downey, John D. (University College Cork, 2020-07)

  This thesis is focused on primary benzenesulfonamides. They have been structurally characterised and analysed for common structural motifs present in the solid state. A systematic investigation of their cocrystallization ...
• Novel synthetic methodology employing organosulfur chemistry in the synthesis of chalcone derivatives 

  Murphy, Chloe C. (University College Cork, 2020-05)

  Highly functionalised a-thio-b-chloroenones are extremely useful synthetic intermediates. Their formation through a N-chlorosuccinimide (NCS) mediated chlorination cascade is a powerful synthetic methodology which transforms ...

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