• An improved synthesis of adefovir and related analogues 

  Jones, David J.; O'Leary, Eileen M.; O'Sullivan, Timothy P. (Beilstein-Institut, 2019-03-29)

  An improved synthesis of the antiviral drug adefovir is presented. Problems associated with current routes to adefovir include capricious yields and a reliance on problematic reagents and solvents, such as magnesium ...
• Alpha-carboxynucleoside phosphonates: direct-acting inhibitors of viral DNA polymerases 

  Balzarini, Jan; Ford, Alan; Maguire, Nuala M.; John, Jubi; Das, Kalyan; Arnold, Eddy; Dehaen, Wim; Maguire, Anita R. (Future Science, 2019-01-16)

  Acyclic nucleoside phosphonates represent a well-defined class of clinically used nucleoside analogs. All acyclic nucleoside phosphonates need intracellular phosphorylation before they can bind viral DNA polymerases. ...
• Desymmetrization by asymmetric copper-catalyzed intramolecular C–H insertion reactions of α-diazo-β-oxosulfones 

  Brouder, Thomas A.; Slattery, Catherine N.; Ford, Alan; Khandavilli, Udaya Bhaskara Rao; Skořepová, Eliška; Eccles, Kevin S.; Lusi, Matteo; Lawrence, Simon E.; Maguire, Anita R. (American Chemical Society, ACS, 2019-03-04)

  Effective desymmetrization in copper-catalyzed intramolecular C–H insertion reactions of α-diazo-β-oxosulfones in the formation of fused thiopyran dioxides is described for the first time. The use of a copper–bis(oxazoline)–NaBARF ...
• Ellipticine derivatives: targeting cell proliferation by a structured approach 

  McKee, Mary (University College Cork, 2019)

  Ellipticine and its derivatives are molecules which possess potent anticancer activity. This thesis explores the synthesis of novel ellipticine derivatives, as well as modifications of the template, and evaluates their ...
• Applications development of broadband acoustic resonance dissolution spectroscopy (BARDS) in the pharmaceutical, food and animal nutrition industries 

  Ahmed, Mohammed Rizwan (University College Cork, 2018)

  Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) is a novel analytical tool for the characterisation of powders, blends, tablets and a myriad of formulations. It is based on a phenomenon which occurs during ...

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