Kruschel, Ryan D.(University College Cork, 2020-07)
This thesis outlines the design and synthesis of novel chemical routes towards a nascent class of functionalised quinoline-5,8-diones and isoquinoline-5,8-diones. The structured approach adopted is predicted to lead to ...
Lyons, Thérèse; Gahan, Cormac G. M.; O'Sullivan, Timothy P.(Newlands Press, 2020-10-23)
Since their initial isolation from the marine alga Delisea pulchra, bromofuranones have been investigated as potential inhibitors of quorum sensing (QS) in various bacterial strains. QS is an important mechanism by which ...
The search for novel nucleosides has been a major research focus in medicinal chemistry for several decades, particularly given their proven track record in the treatment of viral infections and cancer. As bioisosteres of ...
O'Mahony, Rosella M.; Lynch, Denis; Hayes, Hannah L. D.; Ní Thuama, Eilís; Donnellan, Philip; Jones, Roderick C.; Glennon, Brian; Collins, Stuart G.; Maguire, Anita R.(Wiley, 2017-08-21)
The hazardous diazo transfer reagent mesyl azide has been safely generated and used in situ for continuous diazo transfer as part of an integrated synthetic process with an embedded safety quench. Diazo transfer to β‐keto ...
O'Loughlin, Sinéad(University College Cork, 2020-01)
The process of gene expression was long believed to be fixed across all domains of life, set in stone by both the universality of the genetic code and the protein-synthesising machinery that decodes it. However, exceptions ...
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