• Synthesis of nitrogen-containing heterocycles 

  Shanahan, Rachel (University College Cork, 2019-07)

  The sharp rise in antimicrobial resistance has been matched by a decline in the identification and clinical introduction of new classes of drugs to treat microbial infections. Thus new approaches are being sought to target ...
• Innovative synthetic approaches to indazole derivatives and other compounds of pharmaceutical relevance 

  McCarthy, Laura A. (University College Cork, 2019-12-19)

  Synthesis of pharmaceutically active compounds at scale requires a diverse toolkit of powerful synthetic methodologies which effect the necessary molecular transformations coupled with excellent efficiencies and selectivity ...
• Scale-up and optimization of a continuous flow synthesis of an α-thio-βchloroacrylamide 

  Dennehy, Olga C.; Lynch, Denis; Collins, Stuart G.; Maguire, Anita R.; Moynihan, Humphrey A. (American Chemical Society, 2020-05-19)

  Use of continuous flow processing to undertake a multistep chlorination cascade has been achieved with effective inline work-up and end-of-line crystallization in batch leading to isolation of α-thio-β-chloroacrylamide Z-3 ...
• Impurity profiling and synthesis of a series of analogues and isomers of Bromo-DragonFLY 

  Jones, Roisin Anne (University College Cork, 2019-10-01)

  BromoDragon-FLY (BDF) is a highly hallucinogenic amphetamine that fits into a category known as New Psychoactive Substances (NPS), a group of illicit drugs which has risen to prominence in the last two decades. The most ...
• Organolithium bases in flow chemistry: a review 

  Power, Mark; Alcock, Emma; McGlacken, Gerard P. (American Chemical Society, 2020-04-30)

  Flow chemistry is a continually emerging and ever-growing area of synthetic organic chemistry. It provides an orthogonal approach to traditional batch chemistry, oftentimes allowing for more efficient routes to desired ...

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