The work presented in this dissertation focuses on the molecular features of small molecules and their interactions with pharmaceutically relevant molecules. Emphasis is placed on cocrystallisation; a method that facilitates ...

Use of diazo compounds for large scale synthesis has been limited due to the challenges associated with these hazardous reagents; this thesis explores how continuous flow processing can be employed to enable safe generation, ...

In recent years, there has been considerable research focus on natural plant phenolics. They are present as key contributors to the flavour of food and beverages and are also proven to function as antioxidants, providing ...

This thesis describes the telescoping reactions which exploit the diverse catalytic approaches of transition metal catalysis and biocatalysed processes. These processes would normally have conditions that are incompatible. ...

This thesis describes the synthesis of a series of α-diazocarbonyl compounds including α diazo β oxosulfones, α diazo β ketosulfones and an α-diazoketone, and their reactivity in intramolecular copper–bis(oxazoline)–NaBA ...