Investigation of additive effects in enantioselective copper-catalysed C-H insertion and aromatic addition reactions of α-diazocarbonyl compounds

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Date
2012-01
Authors
Slattery, Catherine N.
Clarke, Leslie-Ann
O'Neill, Shane T.
Ring, Aoife
Ford, Alan
Maguire, Anita R.
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Georg Thieme Verlag
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Abstract
Significant enhancements in enantioselectivities and reaction efficiencies in asymmetric copper-catalysed C-H insertion and aromatic addition reactions of α-diazocarbonyl compounds in the presence of various group I salts are reported. For the first time in carbenoid chemistry, evidence for the critical role of the metal cation is described.
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Keywords
C-H insertion , Buchner reaction , Diazocarbonyl , Copper catalysis , Bis(oxazoline) ligands , Carbene insertion , Bonds , Complexes
Citation
Slattery, C. N., Clarke, L. A., O'Neill, S., Ring, A., Ford, A. and Maguire, A. R. (2012) 'Investigation of additive effects in enantioselective copper-catalysed C-H insertion and aromatic addition reactions of α-diazocarbonyl compounds', Synlett, 23(5), pp. 765-767. DOI: 10.1055/s-0031-1290598
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© Georg Thieme Verlag Stuttgart · New York