An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11

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dc.contributor.advisor Mccaffrey, Mary en Timoney, Jennifer Anne 2016-09-16T11:13:23Z 2016 2016
dc.identifier.citation Timoney, J. A .2016. An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11. PhD Thesis, University College Cork. en
dc.description.abstract Rab GTPases are the largest family of the Ras superfamily and are key regulators of membrane trafficking within the cell. There are over 60 members of the Rab family which localise to specific membrane compartments and interact with effector proteins to regulate membrane trafficking processes, such as vesicle formation, vesicle trafficking within the cell and fusion with an acceptor compartment. Multiple effector proteins have been identified for many Rabs, some of which can interact with more than one Rab to link their function at a specific membrane location or to link them together in a Rab activation cascade. Rabin8 is one such protein which is an effector for Rab11a and a Guanine nucleotide Exchange Factor (GEF) for Rab8a. Rabin8 participates in a conserved Rab activation cascade which is critical in the formation of primary cilia. Data presented in this thesis has shown that GRAB interacts with Rab3a, Rab8a, Rab11a and Rab11b in a nucleotide dependent manner. Furthermore, the minimal interacting regionbetween these proteins has been investigated. The functional outcome of GRAB knockdown has also been examined and data in this thesis highlights the phenotypic outcome. en
dc.description.sponsorship Health Research Board (PhD Scholars’ Programme in Cancer Biology) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2016, Jennifer Anne Timoney. en
dc.rights.uri en
dc.subject Rab GTPase en
dc.subject Protein-protein interaction en
dc.subject Endocytosis en
dc.title An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11 en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral Degree (Structured) en
dc.type.qualificationname PhD Scholars Programme in Cancer Biology en
dc.internal.availability Full text not available en Indefinite en 10000-01-01
dc.description.version Accepted Version
dc.contributor.funder Health Research Board en
dc.description.status Not peer reviewed en Biochemistry en Biosciences Institute en
dc.check.reason This thesis is due for publication or the author is actively seeking to publish this material en
dc.check.opt-out Yes en
dc.thesis.opt-out true
dc.check.entireThesis Entire Thesis Restricted
dc.check.embargoformat Both hard copy thesis and e-thesis en
dc.internal.conferring Autumn 2016 en

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© 2016, Jennifer Anne Timoney. Except where otherwise noted, this item's license is described as © 2016, Jennifer Anne Timoney.
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