Gene × environment interactions in schizophrenia: evidence from genetic mouse models

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dc.contributor.author Moran, Paula M.
dc.contributor.author Stokes, Jennifer
dc.contributor.author Marr, Julia
dc.contributor.author Bock, Gavin
dc.contributor.author Desbonnet, Lieve
dc.contributor.author Waddington, John
dc.contributor.author O'Tuathaigh, Colm M. P.
dc.date.accessioned 2016-10-05T15:45:09Z
dc.date.available 2016-10-05T15:45:09Z
dc.date.issued 2016-08-21
dc.identifier.citation Moran, P., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J. and O’Tuathaigh, C. (2016) Gene × environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plasticity, 2173748 (23pp). doi: 10.1155/2016/2173748. en
dc.identifier.startpage 2173748-1 en
dc.identifier.endpage 2173748-23 en
dc.identifier.issn 2090-5904
dc.identifier.uri http://hdl.handle.net/10468/3161
dc.identifier.doi 10.1155/2016/2173748
dc.description.abstract The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in the disorder and is an important consideration as we seek to translate genetic advances into novel antipsychotic treatment targets. This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. Evidence for synergistic effects on the expression of schizophrenia-relevant endophenotypes will be discussed. It is proposed that valid and multifactorial preclinical models are important tools for identifying critical areas, as well as underlying mechanisms, of convergence of genetic and environmental risk factors, and their interaction in schizophrenia. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Hindawi Publishing en
dc.rights © 2016 Paula Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Schizophrenia en
dc.subject Endophenotypes en
dc.subject Etiopathologic basis en
dc.subject Epistatic interactions en
dc.subject Susceptibility genes en
dc.subject Environment interactions en
dc.subject Schizophrenia-relevant endophenotypes en
dc.subject Genetic risk factors en
dc.subject Environmental risk factors en
dc.title Gene × environment interactions in schizophrenia: evidence from genetic mouse models en
dc.type Article (peer-reviewed) en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Neural Plasticity en
dc.internal.copyrightchecked !!CORA!! en
dc.internal.IRISemailaddress c.otuathaigh@ucc.ie en


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© 2016 Paula Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © 2016 Paula Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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