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Diffusible Signal Factor (DSF)-dependent quorum sensing in pathogenic bacteria and its exploitation for disease control
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Date
2016-09-29
Authors
Dow, J. Maxwell
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John Wiley & Sons, Inc.
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Abstract
Cell-to-cell signals of the Diffusible Signal Factor (DSF) family are cis-2-unsaturated fatty acids of differing chain length and branching pattern. DSF signalling has been described in diverse bacteria to include plant and human pathogens where it acts to regulate functions such as biofilm formation, antibiotic tolerance and the production of virulence factors. DSF family signals can also participate in interspecies signalling with other bacteria and interkingdom signaling such as with the yeast Candida albicans. Interference with DSF signalling may afford new opportunities for the control of bacterial disease. Such strategies will depend in part on detailed knowledge of the molecular mechanisms underlying the processes of signal synthesis, perception and turnover. Here, I review both recent progress in understanding DSF signalling at the molecular level and prospects for translating this knowledge into approaches for disease control.
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Keywords
Virulence , Signalling , Plant pathology , Pseudomonads , Microbial physiology
Citation
Dow, J. M. (2016) 'Diffusible Signal Factor (DSF)-dependent quorum sensing in pathogenic bacteria and its exploitation for disease control', Journal of Applied Microbiology, 122(1), pp. 2-11. doi:10.1111/jam.13307
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© 2016, John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Dow, J. M. (2016) 'Diffusible Signal Factor (DSF)-dependent quorum sensing in pathogenic bacteria and its exploitation for disease control', Journal of Applied Microbiology, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/jam.13307/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.