Synergistic nisin-polymyxin combinations for the control of Pseudomonas biofilm formation

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dc.contributor.author Field, Des
dc.contributor.author Seisling, Nynke
dc.contributor.author Cotter, Paul D.
dc.contributor.author Ross, R. Paul
dc.contributor.author Hill, Colin
dc.date.accessioned 2016-10-28T15:38:52Z
dc.date.available 2016-10-28T15:38:52Z
dc.date.issued 2016-10-26
dc.identifier.citation Field, D., Seisling, N., Cotter, P. D., Ross, R. P. and Hill, C. (2016) ‘Synergistic nisin-polymyxin combinations for the control of Pseudomonas biofilm formation. Frontiers in Microbiology, 7, 1713 (7pp). doi: 10.3389/fmicb.2016.01713 en
dc.identifier.volume 7 en
dc.identifier.startpage 1713-1 en
dc.identifier.endpage 1713-7 en
dc.identifier.issn 1664-302X
dc.identifier.uri http://hdl.handle.net/10468/3228
dc.identifier.doi 10.3389/fmicb.2016.01713
dc.description.abstract The emergence and dissemination of multi-drug resistant pathogens is a global concern. Moreover, even greater levels of resistance are conferred on bacteria when in the form of biofilms (i.e., complex, sessile communities of bacteria embedded in an organic polymer matrix). For decades, antimicrobial peptides have been hailed as a potential solution to the paucity of novel antibiotics, either as natural inhibitors that can be used alone or in formulations with synergistically acting antibiotics. Here, we evaluate the potential of the antimicrobial peptide nisin to increase the efficacy of the antibiotics polymyxin and colistin, with a particular focus on their application to prevent biofilm formation of Pseudomonas aeruginosa. The results reveal that the concentrations of polymyxins that are required to effectively inhibit biofilm formation can be dramatically reduced when combined with nisin, thereby enhancing efficacy, and ultimately, restoring sensitivity. Such combination therapy may yield added benefits by virtue of reducing polymyxin toxicity through the administration of significantly lower levels of polymyxin antibiotics. en
dc.description.sponsorship Science Foundation Ireland (SFI Technology and Innovation Development Award (TIDA 14/TIDA/2286), SFI Investigator awards (10/IN.1/B3027), SFI-PI funding (11/PI/1137), (Grant Number SFI/12/RC/2273) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.rights © 2016 Field, Seisling, Cotter, Ross and Hill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Biofilm en
dc.subject Colistin en
dc.subject Polymyxin en
dc.subject Nisin en
dc.subject Lantibiotic en
dc.subject P. aeruginosa en
dc.subject Bacteriocin en
dc.subject Antibiotics en
dc.title Synergistic nisin-polymyxin combinations for the control of Pseudomonas biofilm formation en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Des Field, Microbiology, University College Cork, Cork, Ireland, +353-21-490-3000 Email: Des.Field@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder European Social Fund en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Microbiology en
dc.internal.IRISemailaddress des.field@ucc.ie en


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© 2016 Field, Seisling, Cotter, Ross and Hill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2016 Field, Seisling, Cotter, Ross and Hill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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