Metabolically healthy obesity across the life course: epidemiology, determinants and implications

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dc.contributor.author Phillips, Catherine M.
dc.date.accessioned 2016-11-29T12:40:21Z
dc.date.available 2016-11-29T12:40:21Z
dc.date.issued 2016-10-10
dc.identifier.citation Phillips, C. M. (2016) ‘Metabolically healthy obesity across the life course: epidemiology, determinants, and implications’, Annals of the New York Academy of Sciences, 1391(1), pp. 88-90 doi:10.1111/nyas.13230 en
dc.identifier.volume 1391
dc.identifier.issued 1
dc.identifier.startpage 88
dc.identifier.endpage 100
dc.identifier.issn 1749-6632
dc.identifier.uri http://hdl.handle.net/10468/3320
dc.identifier.doi 10.1111/nyas.13230
dc.description.abstract In recent years, different subphenotypes of obesity have been described, including metabolically healthy obesity (MHO), in which a proportion of obese individuals, despite excess body fat, remain free of metabolic abnormalities and increased cardiometabolic risk. In the absence of a universally accepted set of criteria to classify MHO, the reported prevalence estimates vary widely. Our understanding of the determinants and stability of MHO over time and the associated cardiometabolic and mortality risks is improving, but many questions remain. For example, whether MHO is truly benign is debatable, and whether risk stratification of obese individuals on the basis of their metabolic health status may offer new opportunities for more personalized approaches in diagnosis, intervention, and treatment of diabetes remains speculative. Furthermore, as most of the research to date has focused on MHO in adults, little is known about childhood MHO. In this review, we focus on the epidemiology, determinants, stability, and health implications of MHO across the life course. en
dc.description.sponsorship Health Research Board (HRC/2014/13) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc en
dc.rights © 2016, New York Academy of Sciences. Published by John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Phillips, C. M. (2016) ‘Metabolically healthy obesity across the life course: epidemiology, determinants, and implications’, Annals of the New York Academy of Sciences, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/nyas.13230/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Metabolically healthy obesity en
dc.subject Definitions en
dc.subject Determinants en
dc.subject Stability en
dc.subject Life course en
dc.subject Personalised medicine en
dc.title Metabolically healthy obesity across the life course: epidemiology, determinants and implications en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Catherine Phillips, Epidemiology and Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: c.phillips@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2017-10-10
dc.description.version Accepted Version en
dc.contributor.funder Health Research Board en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Annals of the New York Academy of Sciences en
dc.internal.IRISemailaddress c.phillips@ucc.ie


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