The impact of storage conditions upon gentamicin coated antimicrobial implants

Show simple item record

dc.contributor.author Mullins, Nicholas D.
dc.contributor.author Deadman, Benjamin J.
dc.contributor.author Moynihan, Humphrey A.
dc.contributor.author McCarthy, Florence O.
dc.contributor.author Lawrence, Simon E.
dc.contributor.author Thompson, Jonathan
dc.contributor.author Maguire, Anita R.
dc.date.accessioned 2016-12-14T10:33:26Z
dc.date.available 2016-12-14T10:33:26Z
dc.date.issued 2016-05-26
dc.identifier.citation Mullins, N. D., Deadman, B. J., Moynihan, H. A., McCarthy, F. O., Lawrence, S. E., Thompson, J. and Maguire, A. R. (2016) 'The impact of storage conditions upon gentamicin coated antimicrobial implants', Journal of Pharmaceutical Analysis, 6(6), pp. 374-381. doi:10.1016/j.jpha.2016.05.002 en
dc.identifier.volume 6 en
dc.identifier.issued 6 en
dc.identifier.startpage 374 en
dc.identifier.endpage 381 en
dc.identifier.issn 2095-1779
dc.identifier.uri http://hdl.handle.net/10468/3378
dc.identifier.doi 10.1016/j.jpha.2016.05.002
dc.description.abstract A systematic approach was developed to investigate the stability of gentamicin sulfate (GS) and GS/poly (lactic-co-glycolic acid) (PLGA) coatings on hydroxyapatite surfaces. The influence of environmental factors (light, humidity, oxidation and heat) upon degradation of the drug in the coatings was investigated using liquid chromatography with evaporative light scattering detection and mass spectrometry. GS coated rods were found to be stable across the range of environments assessed, with only an oxidizing atmosphere resulting in significant changes to the gentamicin composition. In contrast, rods coated with GS/PLGA were more sensitive to storage conditions with compositional changes being detected after storage at 60 °C, 75% relative humidity or exposure to light. The effect of γ-irradiation on the coated rods was also investigated and found to have no significant effect. Finally, liquid chromatography–mass spectrometry analysis revealed that known gentamines C1, C1a and C2 were the major degradants formed. Forced degradation of gentamicin coatings did not produce any unexpected degradants or impurities. en
dc.description.sponsorship DePuy Synthes (Ireland); Enterprise Ireland (IP 2010-0068) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2016 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Gentamicin en
dc.subject Storage stability testing en
dc.subject LC–ELSD en
dc.subject Coatings en
dc.title The impact of storage conditions upon gentamicin coated antimicrobial implants en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Anita Maguire, Vice President For Research, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.maguire@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2016-12-13T11:43:35Z
dc.description.version Published Version en
dc.internal.rssid 375528298
dc.contributor.funder Enterprise Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Pharmaceutical and Biomedical Analysis en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress a.maguire@ucc.ie en
dc.internal.IRISemailaddress simon.lawrence@ucc.ie en
dc.internal.IRISemailaddress f.mccarthy@ucc.ie en


Files in this item

This item appears in the following Collection(s)

Show simple item record

© 2016 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license Except where otherwise noted, this item's license is described as © 2016 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement