The microbiome and the pathophysiology of asthma

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dc.contributor.author Sullivan, Ashley
dc.contributor.author Hunt, Eoin
dc.contributor.author MacSharry, John
dc.contributor.author Murphy, Desmond M.
dc.date.accessioned 2016-12-20T09:30:50Z
dc.date.available 2016-12-20T09:30:50Z
dc.date.issued 2016-12-05
dc.identifier.citation Sullivan, A., Hunt, E., MacSharry, J., Murphy, D. M. (2016) 'The microbiome and the pathophysiology of asthma', Respiratory Research, 17:163 (11pp). doi:10.1186/s12931-016-0479-4 en
dc.identifier.volume 17 en
dc.identifier.startpage 1 en
dc.identifier.endpage 11 en
dc.identifier.issn 1465-993X
dc.identifier.uri http://hdl.handle.net/10468/3398
dc.identifier.doi 10.1186/s12931-016-0479-4
dc.description.abstract Asthma is a chronic respiratory disease whose prevalence is increasing in the western world. Recently research has begun to focus on the role the microbiome plays in asthma pathogenesis in the hope of further understanding this respiratory disorder. Considered sterile until recently, the lungs have revealed themselves to contain a unique microbiota. A shift towards molecular methods for the quantification and sequencing of microbial DNA has revealed that the airways harbour a unique microbiota with apparent, reproducible differences present between healthy and diseased lungs. There is a hope that in classifying the microbial load of the asthmatic airway an insight may be afforded as to the possible role pulmonary microbes may have in propagating an asthmatic airway response. This could potentially pave the way for new therapeutic strategies for the treatment of chronic lung conditions such as asthma. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BioMed Central en
dc.rights © 2016, the Authors. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Asthma en
dc.subject Host en
dc.subject Microbe dialogue en
dc.subject Translational research en
dc.subject Medicine en
dc.subject Inflammation en
dc.subject Microbiology en
dc.subject Epithelium en
dc.subject Hygiene hypothesis en
dc.title The microbiome and the pathophysiology of asthma en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John MacSharry, Medical School Office, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.macsharry@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2016-12-19T13:10:35Z
dc.description.version Published Version en
dc.internal.rssid 376291664
dc.contributor.funder Wilton Respiratory Research Fund
dc.contributor.funder APC Microbiome Institute, College of Medicine and Health, University College Cork
dc.description.status Peer reviewed en
dc.identifier.journaltitle Respiratory Research en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.macsharry@ucc.ie en
dc.identifier.articleid 163


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© 2016, the Authors. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Except where otherwise noted, this item's license is described as © 2016, the Authors. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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