Establishment and development of infant gut microbiota

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dc.contributor.advisor Stanton, Catherine en
dc.contributor.advisor O'Toole, Paul W. en Hill, Cian J. 2017-01-06T10:05:28Z 2015 2016
dc.identifier.citation Hill, C. 2015. Establishment and development of infant gut microbiota. PhD Thesis, University College Cork. en
dc.description.abstract The nascent gut microbiota at birth is established in concert with numerous developmental parameters. Here, in the INFAMTET study, we chronicled the impact of some factors which are key determinants of the infant gut microbiota, namely; mode of birth, gestational age, and type of feeding. We determined that the aggregated microbiota profile of naturally delivered, initially breastfed infants are relatively stable from one week to six months of age and are not significantly altered by increased duration of breastfeeding. Contrastingly, there is significant development of the microbiota profile of C-section delivered infants, and this development is significantly influenced by breastfeeding duration. Preterm infants, born by either mode of birth, initially have a high proportion of Proteobacteria, and demonstrate significant development of the gut microbiota from week 1 to later time-points. The microbiota is still slightly, but significantly, affected by birth mode at one year of age although no specific genera were found to be significantly altered in relative abundance. By two years of age, there is no effect of either birth mode or gestational age. However this does not preclude the possibility that symptoms developed later in life, which are associated with preterm or C-section birth, are as a result of the early perturbation of the neonatal gut microbiota. It is likely that the combination of relatively low exposure (breast fed), high exposure (formula fed) or delayed exposure (C-section and preterm) to specific antigens and the resulting inflammatory responses, in this crucial window of host-microbiota interaction, influence systemic health of the individual throughout life. en
dc.description.sponsorship Department of Agriculture, Food and the Marine, Ireland (INFANTMET) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2015, Cian Hill. en
dc.rights.uri en
dc.subject Intestinal microbiota en
dc.title Establishment and development of infant gut microbiota en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Science) en
dc.internal.availability Full text not available en Indefinite en 10000-01-01
dc.description.version Accepted Version
dc.contributor.funder Department of Agriculture, Food and the Marine, Ireland en
dc.description.status Not peer reviewed en Alimentary Pharmabotic Centre en Microbiology en Teagasc en
dc.check.type No Embargo Required
dc.check.reason This thesis is due for publication or the author is actively seeking to publish this material en
dc.check.opt-out Not applicable en
dc.thesis.opt-out true
dc.check.embargoformat Both hard copy thesis and e-thesis en
dc.internal.conferring Summer 2016 en

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© 2015, Cian Hill. Except where otherwise noted, this item's license is described as © 2015, Cian Hill.
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