Early life exposure to chronic intermittent hypoxia primes increased susceptibility to hypoxia-induced weakness in rat sternohyoid muscle during adulthood

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dc.contributor.author McDonald, Fiona B.
dc.contributor.author Dempsey, Eugene M.
dc.contributor.author O'Halloran, Ken D.
dc.date.accessioned 2017-01-09T16:37:20Z
dc.date.available 2017-01-09T16:37:20Z
dc.date.issued 2016-03-04
dc.identifier.citation McDonald, F. B., Dempsey, E. M. and O'Halloran, K. D. (2016) 'Early life exposure to chronic intermittent hypoxia primes increased susceptibility to hypoxia-induced weakness in rat sternohyoid muscle during adulthood', Frontiers in Physiology, 7, 69 (11pp). doi:10.3389/fphys.2016.00069 en
dc.identifier.volume 7 en
dc.identifier.startpage 69-1 en
dc.identifier.endpage 69-11 en
dc.identifier.issn 1664-042X
dc.identifier.uri http://hdl.handle.net/10468/3454
dc.identifier.doi 10.3389/fphys.2016.00069
dc.description.abstract Intermittent hypoxia is a feature of apnea of prematurity (AOP), chronic lung disease, and sleep apnea. Despite the clinical relevance, the long-term effects of hypoxic exposure in early life on respiratory control are not well defined. We recently reported that exposure to chronic intermittent hypoxia (CIH) during postnatal development (pCIH) causes upper airway muscle weakness in both sexes, which persists for several weeks. We sought to examine if there are persistent sex-dependent effects of pCIH on respiratory muscle function into adulthood and/or increased susceptibility to re-exposure to CIH in adulthood in animals previously exposed to CIH during postnatal development. We hypothesized that pCIH would cause long-lasting muscle impairment and increased susceptibility to subsequent hypoxia. Within 24 h of delivery, pups and their respective dams were exposed to CIH: 90 s of hypoxia reaching 5% O2 at nadir; once every 5 min, 8 h per day for 3 weeks. Sham groups were exposed to normoxia in parallel. Three groups were studied: sham; pCIH; and pCIH combined with adult CIH (p+aCIH), where a subset of the pCIH-exposed pups were re-exposed to the same CIH paradigm beginning at 13 weeks. Following gas exposures, sternohyoid and diaphragm muscle isometric contractile and endurance properties were examined ex vivo. There was no apparent lasting effect of pCIH on respiratory muscle function in adults. However, in both males and females, re-exposure to CIH in adulthood in pCIH-exposed animals caused sternohyoid (but not diaphragm) weakness. Exposure to this paradigm of CIH in adulthood alone had no effect on muscle function. Persistent susceptibility in pCIH-exposed airway dilator muscle to subsequent hypoxic insult may have implications for the control of airway patency in adult humans exposed to intermittent hypoxic stress during early life. en
dc.description.sponsorship University College Dublin (School of Medicine and Medical Science) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.rights © 2016 McDonald, Dempsey and O’Halloran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Apnea en
dc.subject Developmental plasticity en
dc.subject Neonatal en
dc.subject Respiratory muscle dysfunction en
dc.subject Upper airway patency en
dc.title Early life exposure to chronic intermittent hypoxia primes increased susceptibility to hypoxia-induced weakness in rat sternohyoid muscle during adulthood en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ken O'Halloran, Physiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: k.ohalloran@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-01-09T16:31:47Z
dc.description.version Published Version en
dc.internal.rssid 334519261
dc.internal.rssid 395506625
dc.contributor.funder Health Research Board en
dc.contributor.funder University College Dublin en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Physiology en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress g.dempsey@ucc.ie
dc.internal.IRISemailaddress k.ohalloran@ucc.ie en
dc.internal.IRISemailaddress fiona.mcdonald@ucc.ie en


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© 2016 McDonald, Dempsey and O’Halloran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2016 McDonald, Dempsey and O’Halloran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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