The Trier Social Stress Test: principles and practice

Show simple item record Allen, Andrew P. Kennedy, Paul J. Dockray, Samantha Cryan, John F. Dinan, Timothy G. Clarke, Gerard 2017-01-10T11:41:57Z 2017-01-10T11:41:57Z 2016-11-12
dc.identifier.citation Allen, A. P., Kennedy, P. J., Dockray, S., Cryan, J. F., Dinan, T. G. and Clarke, G. (2017) 'The Trier Social Stress Test: Principles and practice', Neurobiology of Stress, 6, pp. 113-126. doi:10.1016/j.ynstr.2016.11.001 en
dc.identifier.volume 6
dc.identifier.startpage 113
dc.identifier.endpage 126
dc.identifier.issn 2352-2895
dc.identifier.doi 10.1016/j.ynstr.2016.11.001
dc.description.abstract Researchers interested in the neurobiology of the acute stress response in humans require a valid and reliable acute stressor that can be used under experimental conditions. The Trier Social Stress Test (TSST) provides such a testing platform. It induces stress by requiring participants to make an interview-style presentation, followed by a surprise mental arithmetic test, in front of an interview panel who do not provide feedback or encouragement. In this review, we outline the methodology of the TSST, and discuss key findings under conditions of health and stress-related disorder. The TSST has unveiled differences in males and females, as well as different age groups, in their neurobiological response to acute stress. The TSST has also deepened our understanding of how genotype may moderate the cognitive neurobiology of acute stress, and exciting new inroads have been made in understanding epigenetic contributions to the biological regulation of the acute stress response using the TSST. A number of innovative adaptations have been developed which allow for the TSST to be used in group settings, with children, in combination with brain imaging, and with virtual committees. Future applications may incorporate the emerging links between the gut microbiome and the stress response. Future research should also maximise use of behavioural data generated by the TSST. Alternative acute stress paradigms may have utility over the TSST in certain situations, such as those that require repeat testing. Nonetheless, we expect that the TSST remains the gold standard for examining the cognitive neurobiology of acute stress in humans. en
dc.description.sponsorship Health Research Board, (HRB) through Health Research Awards (grant number HRA_-POR_2014_647; GC, TGD)); Science Foundation Ireland (SFI grant number SFI/12/RC/2273). en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2016, The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( en
dc.rights.uri en
dc.subject Stress en
dc.subject Cognition en
dc.subject HPA axis en
dc.subject Epigenetics en
dc.subject Genotype en
dc.title The Trier Social Stress Test: principles and practice en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Gerard Clarke, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en 2017-01-10T11:37:42Z
dc.description.version Published Version en
dc.internal.rssid 374001279
dc.contributor.funder Health Research Board en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Neurobiology of Stress en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en

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© 2016, The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( Except where otherwise noted, this item's license is described as © 2016, The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (
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