The impact of whey protein consumption and exercise on the composition and diversity of the gut microbiota: a high through-put DNA sequencing approach

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dc.contributor.advisor Cotter, Paul en
dc.contributor.advisor Fitzgerald, Gerald F. en
dc.contributor.author Skuse, Peter H
dc.date.accessioned 2017-01-12T11:16:02Z
dc.date.available 2017-01-12T11:16:02Z
dc.date.issued 2015
dc.date.submitted 2015
dc.identifier.citation Skuse, P. H. 2015. The impact of whey protein consumption and exercise on the composition and diversity of the gut microbiota: a high through-put DNA sequencing approach. PhD Thesis, University College Cork. en
dc.identifier.endpage 313 en
dc.identifier.uri http://hdl.handle.net/10468/3466
dc.description.abstract Advances in culture independent technologies over the last decade have highlighted the pivotal role which the gut microbiota plays in maintaining human health. Conversely, perturbations to the composition or actions of the ‘normal/functioning’ microbiota have been frequently associated with the pathogenesis of several disease states. Therefore the selective modulation of enteric microbial communities represents a viable target for the development of novel treatments for such diseases. Notably, while bovine whey proteins and exercise have been shown to positively influence several physiological processes, such as energy balance, their effect on the composition or functionality of the gut microbiota remains largely unknown. In this thesis, a variety of ex vivo, murine and human models are used in conjunction with high-throughput DNA sequencing-based analysis to provide valuable and novel insights into the impact of both whey proteins and exercise on enteric microbial communities. Overall the results presented in this thesis highlight that the consumption both whey protein isolate (WPI), and individual component proteins of whey such as bovine serum albumin (BSA) and lactoferrin, reduce high fat diet associated body weight gain and are associated with beneficial alterations within the murine gut microbiota. Although the impact of exercise on enteric microbial communities remains less clear, it may be that longer term investigations are required for the true effect of exercise on the gut microbiota to be fully elucidated. en
dc.description.sponsorship Teagasc (Walsh Fellowship Scheme) en
dc.format.mimetype application/pdf en
dc.language English en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2015, Peter H Skuse. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Microbiology en
dc.subject DNA sequencing en
dc.subject Whey protein en
dc.subject Exercise en
dc.subject Gut microbiota en
dc.title The impact of whey protein consumption and exercise on the composition and diversity of the gut microbiota: a high through-put DNA sequencing approach en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Science) en
dc.internal.availability Full text available en
dc.check.info No embargo required en
dc.description.version Accepted Version
dc.contributor.funder Teagasc en
dc.description.status Not peer reviewed en
dc.internal.school Microbiology en
dc.internal.school Teagasc en
dc.check.type No Embargo Required
dc.check.reason No embargo required en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.embargoformat Not applicable en
ucc.workflow.supervisor g.fitzgerald@ucc.ie
dc.internal.conferring Spring 2016 en


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© 2015, Peter H Skuse. Except where otherwise noted, this item's license is described as © 2015, Peter H Skuse.
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