Incidence of surgical site infection following caesarean section: a systematic review and meta-analysis protocol

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dc.contributor.author Saeed, Khalid B. M.
dc.contributor.author Greene, Richard A.
dc.contributor.author Corcoran, Paul
dc.contributor.author O'Neill, Sinéad M.
dc.date.accessioned 2017-01-23T14:57:24Z
dc.date.available 2017-01-23T14:57:24Z
dc.date.issued 2017-01-01
dc.identifier.citation Saeed, K. B. M., Greene, R. A., Corcoran, P. and O'Neill, S. M. (2017) 'Incidence of surgical site infection following caesarean section: a systematic review and meta-analysis protocol', BMJ Open, 7(1). doi:10.1136/bmjopen-2016-013037 en
dc.identifier.volume 7 en
dc.identifier.issued 1 en
dc.identifier.startpage e013037-1 en
dc.identifier.endpage e013037-5 en
dc.identifier.issn 2044-6055
dc.identifier.uri http://hdl.handle.net/10468/3503
dc.identifier.doi 10.1136/bmjopen-2016-013037
dc.description.abstract Introduction: Caesarean section (CS) rates have increased globally during the past three decades. Surgical site infection (SSI) following CS is a common cause of morbidity with reported rates of 3 -15%. SSI represents a substantial burden to the health system including increased length of hospitalisation and costs of postdischarge care. The definition of SSI varies with the postoperative follow-up period among different health systems, resulting in differences in the reporting of SSI incidence. We propose to conduct the first systematic review and meta-analysis to determine the pooled estimate for the overall incidence of SSI following CS. Methods and analysis: We will perform a comprehensive search to identify all potentially relevant published studies on the incidence of SSI following CS reported from 1992 in the English language. Electronic databases including PubMed, CINAHL, EMBASE and Scopus will be searched using a detailed search strategy. Following study selection, full-text paper retrieval, data extraction and synthesis, we will appraise study quality and risk of bias and assess heterogeneity. Incidence data will be combined where feasible in a meta-analysis using Stata software and fixed-effects or random-effects models as appropriate. This systematic review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Ethics and dissemination: Ethical approval is not required as this review will use published data. The review will evaluate the overall incidence of SSI following CS and will provide the first quantitative estimate of the magnitude of SSI. It will serve as a benchmark for future studies, identify research gaps and remaining challenges, and emphasise the need for appropriate prevention and control measures for SSI post-CS. A manuscript reporting the results of the systematic review and meta-analysis will be submitted to a peer-reviewed journal and presented at scientific conferences. Trial registration number CRD42015024426. en
dc.description.sponsorship University College Cork (Department of Obstetrics and Gynaecology) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BMJ Publishing Group en
dc.rights © 2017, The Authors. Published by the BMJ Publishing Group Limited. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject Caesarean section rates en
dc.subject Surgical site infection (SSI) en
dc.subject SSI incidence en
dc.subject Post-CS surgical site infection en
dc.title Incidence of surgical site infection following caesarean section: a systematic review and meta-analysis protocol en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Sinéad O'Neill, Obstetrics & Gynaecology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: sinead.oneill@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-01-23T14:47:39Z
dc.description.version Published Version en
dc.internal.rssid 380746171
dc.contributor.funder University College Cork en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Bmj Open en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress sinead.oneill@ucc.ie en


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© 2017, The Authors. Published by the BMJ Publishing Group Limited. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Except where otherwise noted, this item's license is described as © 2017, The Authors. Published by the BMJ Publishing Group Limited. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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