Pharmacotherapy for neonatal seizures: current knowledge and future perspectives

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dc.contributor.author Donovan, Maria D.
dc.contributor.author Griffin, Brendan T.
dc.contributor.author Kharoshankaya, Liudmila
dc.contributor.author Cryan, John F.
dc.contributor.author Boylan, Geraldine B.
dc.date.accessioned 2017-01-30T11:51:54Z
dc.date.available 2017-01-30T11:51:54Z
dc.date.issued 2016-03-04
dc.identifier.citation Donovan, M. D., Griffin, B. T., Kharoshankaya, L., Cryan, J. F. and Boylan, G. B. (2016) 'Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives', Drugs, 76(6), pp. 647-661. doi:10.1007/s40265-016-0554-7 en
dc.identifier.volume 76 en
dc.identifier.startpage 647 en
dc.identifier.endpage 661 en
dc.identifier.issn 0012-6667
dc.identifier.uri http://hdl.handle.net/10468/3537
dc.identifier.doi 10.1007/s40265-016-0554-7
dc.description.abstract Seizures are the most common neurological emergencies in the neonatal period and are associated with poor neurodevelopmental outcomes. Seizures affect up to five per 1000 term births and population-based studies suggest that they occur even more frequently in premature infants. Seizures are a sign of an underlying cerebral pathology, the most common of which is hypoxic-ischaemic encephalopathy in term infants. Due to a growing body of evidence that seizures exacerbate cerebral injury, effective diagnosis and treatment of neonatal seizures is of paramount importance to reduce long-term adverse outcomes. Electroencephalography is essential for the diagnosis of seizures in neonates due to their subtle clinical expression, non-specific neurological presentation and a high frequency of electro-clinical uncoupling in the neonatal period. Hypoxic-ischaemic encephalopathy may require neuroprotective therapeutic hypothermia, accompanying sedation with opioids, anticonvulsant drugs or a combination of all of these. The efficacy, safety, tolerability and pharmacokinetics of seven anticonvulsant drugs (phenobarbital, phenytoin, levetiracetam, lidocaine, midazolam, topiramate and bumetanide) are reviewed. This review is focused only on studies reporting electrographically confirmed seizures and highlights the knowledge gaps that exist in optimal treatment regimens for neonatal seizures. Randomised controlled trials are needed to establish a safe and effective treatment protocol for neonatal seizures. en
dc.description.sponsorship Irish Research Council for Science Engineering and Technology scholarship; Science Foundation Ireland (SFI centre grant (INFANT SFI/12/RC/2272), Centre Grant Number SFI/12/RC/2273); Health Research Board of Ireland (Grant Numbers HRA_POR/2011/23 and HRA_POR/2012/32) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Verlag; Adis en
dc.rights © Springer International Publishing Switzerland 2016. The final publication is available at Springer via http://dx.doi.org/10.1007/s40265-016-0554-7 en
dc.subject Hypoxic-ischemic encephalopathy en
dc.subject Augments hypothermic neuroprotection en
dc.subject Whole-body hypothermia en
dc.subject Therapeutic hypothermia en
dc.subject Brain injury en
dc.subject Electrographic seizures en
dc.subject Antiepileptic drugs en
dc.subject Perinatal asphyxia en
dc.subject Intravenous levetiracetam en
dc.subject Population pharmacokinetics en
dc.title Pharmacotherapy for neonatal seizures: current knowledge and future perspectives en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Maria Donovan, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: mariadonovan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by the request of the publisher. en
dc.check.date 2017-03-04
dc.date.updated 2017-01-30T11:34:38Z
dc.description.version Accepted Version en
dc.internal.rssid 381636937
dc.internal.rssid 344824904
dc.internal.wokid WOS:000375052400003
dc.contributor.funder Irish Research Council for Science, Engineering and Technology en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder European Commission en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Drugs en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress mariadonovan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/241479/EU/Treatment of NEonatal seizures with Medication Off-patent: evaluation of efficacy and safety of bumetanide/NEMO en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/278948/EU/Translational Adolescent and Childhood Therapeutic Interventions in Compulsive Syndromes/TACTICS en


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