The microbiome-gut-brain axis in health and disease

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dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.date.accessioned 2017-01-31T11:18:10Z
dc.date.available 2017-01-31T11:18:10Z
dc.date.issued 2017-01-04
dc.identifier.citation Dinan, T. G. and Cryan, J. F. (2017) 'The microbiome-gut-brain axis in health and disease', Gastroenterology Clinics of North America, 46(1), pp. 77-89. doi:10.1016/j.gtc.2016.09.007 en
dc.identifier.volume 46
dc.identifier.issued 1
dc.identifier.startpage 77
dc.identifier.endpage 89
dc.identifier.issn 0889-8553
dc.identifier.uri http://hdl.handle.net/10468/3544
dc.identifier.doi 10.1016/j.gtc.2016.09.007
dc.description.abstract Gut microbes are capable of producing most neurotransmitters found in the human brain. While these neurotransmitters primarily act locally in the gut, modulating the enteric nervous system, evidence is now accumulating to support the view that gut microbes through multiple mechanisms can influence central neurochemistry and behavior. This has been described as a fundamental paradigm shift in neuroscience. Bifidobacteria for example can produce and increase plasma levels of the serotonin precursor tryptophan, which is fundamental in regulating mood, appetite and gastrointestinal function. Certain Lactobacilli have been shown to produce gamma-aminobutyric acid (GABA) and to alter brain GABA receptor expression and behavior. IBS is regarded as the prototypic disorder of the brain-gut-microbiota axis which can be responsive to probiotic therapy. Recently, the concept of a psychobiotic has been introduced in the literature. A psychobiotic is a bacteria which when ingested in adequate amounts can have a positive mental health benefit. Translational studies indicate that certain bacteria may impact upon stress responses and cognitive functioning. Manipulating the gut microbiota with psychobiotics, prebiotics or even antibiotics offers a novel approach to altering brain function and treating gut-brain axis disorders such as depression and autism. en
dc.description.sponsorship Science Foundation Ireland (Alimentary Pharmabiotic Centre Grant Number SFI/12/RC/2273); Health Research Board (Grant Numbers HRA_POR/2011/23 and HRA_POR/2012/32); European Commission (Seventh Framework Programme: MyNewGut Grant Agreement No. FP7/2007-2013) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Inc en
dc.rights © 2016, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Microbiota en
dc.subject Psychobiotics en
dc.subject Short-chain fatty acids en
dc.subject Vagus nerve en
dc.subject GABA en
dc.subject Serotonin en
dc.title The microbiome-gut-brain axis in health and disease en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ted Dinan, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.dinan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-01-31T10:01:52Z
dc.description.version Accepted Version en
dc.internal.rssid 381637053
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Seventh Framework Programme en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Gastroenterology Clinics of North America en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT en


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© 2016, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2016, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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