Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.

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dc.contributor.author Hegarty, Shane V.
dc.contributor.author O'Keefe, Gerard W.
dc.contributor.author Sullivan, Aideen M.
dc.date.accessioned 2017-02-13T15:34:24Z
dc.date.available 2017-02-13T15:34:24Z
dc.date.issued 2014-10
dc.identifier.citation Hegarty, S.V., O’Keeffe, G.W. and Sullivan, A. M. (2014) 'Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease', Neural Regeneration Research, 9(19), pp. 1708-1711. doi:10.4103/1673-5374.143410 en
dc.identifier.volume 9 en
dc.identifier.issued 19 en
dc.identifier.startpage 1708 en
dc.identifier.endpage 1711 en
dc.identifier.issn 1673-5374
dc.identifier.uri http://hdl.handle.net/10468/3623
dc.identifier.doi 10.4103/1673-5374.143410
dc.description.abstract Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson’s disease. In Parkinson’s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5. en
dc.description.sponsorship Irish Research Council (R13702 and R15897); Health Research Board of Ireland (HRA/2009/127); Science Foundation Ireland (10/RFP/NES27860) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Medknow Publications en
dc.rights © Neural Regeneration Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/3.0/ en
dc.subject Neuroprotection en
dc.subject Neurotrophic factors en
dc.subject Nervous system development; en
dc.subject Nigrostriatal dopaminergic neurons en
dc.subject Glial cell line-derived neurotrophic factor en
dc.subject Neurturin en
dc.subject Growth/differentiation factor 5 en
dc.subject Parkinson's disease en
dc.title Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease. en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Shane Hegarty, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: shane.hegarty@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-02-13T15:17:43Z
dc.description.version Published Version en
dc.internal.rssid 277735799
dc.contributor.funder Irish Research Council en
dc.contributor.funder Health Research Board en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Neural Regeneration Research en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress shane.hegarty@ucc.ie en


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© Neural Regeneration Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © Neural Regeneration Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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