Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.
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Published Version
Date
2014-10
Authors
Hegarty, Shane V.
O'Keefe, Gerard W.
Sullivan, Aideen M.
Journal Title
Journal ISSN
Volume Title
Publisher
Medknow Publications
Published Version
Abstract
Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson’s disease. In Parkinson’s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.
Description
Keywords
Neuroprotection , Neurotrophic factors , Nervous system development; , Nigrostriatal dopaminergic neurons , Glial cell line-derived neurotrophic factor , Neurturin , Growth/differentiation factor 5 , Parkinson's disease
Citation
Hegarty, S.V., O’Keeffe, G.W. and Sullivan, A. M. (2014) 'Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease', Neural Regeneration Research, 9(19), pp. 1708-1711. doi:10.4103/1673-5374.143410