• Quality indicators for hospital antimicrobial stewardship programmes: a systematic review 

  O'Riordan, Frank; Shiely, Frances; Byrne, Stephen; Fleming, Aoife (Oxford University Press, 2021-03-31)

  Measuring the quality and effectiveness of antimicrobial stewardship (AMS) programmes with quality indicators (QIs) is an area of increasing interest. We conducted a systematic review to identify QIs of AMS programmes in ...
• Recent advances in the transesterification of β-keto esters 

  Hennessy, Mary C.; O'Sullivan, Timothy P. (Royal Society of Chemistry, 2021-07-02)

  The ability to selectively transesterify β-keto esters is a useful transformation in organic synthesis. The increasing interest in transesterification for the synthesis of compounds of pharmaceutical importance, as well ...
• Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage – case study of Venetoclax 

  Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Holm, René; Vertzoni, Maria; Griffin, Brendan T. (Elsevier, 2021-04-15)

  The pig has been increasingly used as a reliable preclinical model for assessing and predicting the in vivo bioavailability of different formulation strategies. Nevertheless, differences in the composition between porcine ...
• Characterization of gastrointestinal transit and luminal conditions in pigs using a telemetric motility capsule 

  Henze, Laura J.; Koehl, Niklas J.; Bennett-Lenane, Harriet; Holm, René; Grimm, Michael; Schneider, Felix; Weitschies, Werner; Koziolek, Mirko; Griffin, Brendan T. (Elsevier, 2020-10-27)

  Within preclinical research, the pig has become an important model in regulatory toxicology and pharmacokinetics, to assess oral dosage forms and to compare different formulation strategies. In addition, there are emerging ...
• Exploring the utility of lipid-based formulation technology to enhance oral bioavailability of BCS class IV molecules 

  Köhl, Niklas J. (University College Cork, 2020-04-30)

  Purpose: Increasing numbers of poorly water-soluble drugs emerging from discovery pipelines have led to formulation delivery challenges. Poorly water-soluble drugs that exhibit limited in vivo bioavailability generate a ...

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