• Localized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurity 

  Flynn, Aaran J.; Ford, Alan; Maguire, Anita R. (American Chemical Society, 2020-07-02)

  Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation ...
• Novel biphasic lipolysis method to predict in vivo performance of lipid-based formulations 

  O'Dwyer, Patrick J; Box, Karl J; Koehl, Niklas J; Bennett-Lenane, Harriet; Reppas, Christos; Holm, Rene; Kuentz, Martin; Griffin, Brendan T (American Chemical Society, 2020-08-06)

  The absence of an intestinal absorption sink is a significant weakness of standard in vitro lipolysis methods, potentially leading to poor prediction of in vivo performance and an overestimation of drug precipitation. In ...
• A retrospective biopharmaceutical analysis of >800 approved oral drug products: Are drug properties of solid dispersions and lipid-based formulations distinctive? 

  Bennett-Lenane, Harriet; O'Shea, Joseph P.; O'Driscoll, Caitriona M.; Griffin, Brendan T. (Elsevier Inc., 2020-08-19)

  Increasing numbers of poorly water soluble drugs in development has intensified need for bio-enabling formulations including Lipid-Based Formulations (LBF) and Solid Dispersions (SD). Resultantly, a data-driven approach ...
• Identifying behavior change techniques for inclusion in a complex intervention targeting antipsychotic prescribing to nursing home residents with dementia 

  Walsh, Kieran A.; Timmons, Suzanne; Byrne, Stephen; Browne, John; Mc Sharry, Jenny (Oxford University Press, 2020-06-26)

  Nursing home residents with dementia are commonly prescribed antipsychotics despite the associated increased risk of harms. Interventions to optimize prescribing practice have been found to be effective in the short term, ...
• Taming tosyl azide: the development of a scalable continuous diazo transfer process 

  Deadman, Benjamin J.; O'Mahony, Rosella M.; Lynch, Denis; Crowley, Daniel C.; Collins, Stuart G.; Maguire, Anita R. (Royal Society of Chemistry, 2016-03-01)

  Heat and shock sensitive tosyl azide was generated and used on demand in a telescoped diazo transfer process. Small quantities of tosyl azide were accessed in a 'one pot' batch procedure using shelf stable, readily available ...

View more