• Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption 

  Ilie, Alexandra-Roxana; Griffin, Brendan T.; Brandl, Martin; Bauer-Brandl, Annette; Jacobsen, Ann-Christin; Vertzoni, Maria; Kuentz, Martin; Kolakovic, Ruzica; Holm, René (Elsevier B.V., 2020-07-03)

  Supersaturated lipid-based drug delivery systems have recently been investigated for oral administration for a variety of lipophilic drugs and have shown either equivalent or superior oral bioavailability compared to ...
• Supersaturated lipid-based formulations to enhance the oral bioavailability of venetoclax 

  Koehl, Niklas J.; Henze, Laura J.; Kuentz, Martin; Holm, René; Griffin, Brendan T. (MDPI, 2020-06-18)

  Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. ...
• Chase dosing of lipid formulations to enhance oral bioavailability of nilotinib in rats 

  Koehl, Niklas J.; Holm, René; Kuentz, Martin; Griffin, Brendan T. (Springer Nature Switzerland AG, 2020-06-10)

  Purpose: Lipid-based formulations (LBF) have shown oral bioavailability enhancement of lipophilic drugs, but not necessarily in the case of hydrophobic drugs. This study explored the potential of lipid vehicles to improve ...
• Synthetic and mechanistic aspects of sulfonyl migrations 

  Flynn, Aaran J.; Ford, Alan; Maguire, Anita R. (Royal Society of Chemistry, 2020-02-03)

  Over the past 20 years reports of sulfonyl migrations have appeared, frequently described as ‘unusual’ and ‘unexpected’. This comprehensive review compiles, for the first time, sulfonyl migrations reported over the last ...
• Scale-up and optimization of a continuous flow synthesis of an α-thio-βchloroacrylamide 

  Dennehy, Olga C.; Lynch, Denis; Collins, Stuart G.; Maguire, Anita R.; Moynihan, Humphrey A. (American Chemical Society, 2020-05-19)

  Use of continuous flow processing to undertake a multistep chlorination cascade has been achieved with effective inline work-up and end-of-line crystallization in batch leading to isolation of α-thio-β-chloroacrylamide Z-3 ...

View more