Signatures of early frailty in the gut microbiota

CORA will be unavailable from 08:00- 09:00 for regular maintenance on Tuesday, 28th May 2019. Apologies for any inconvenience this may cause.

Show simple item record

dc.contributor.author Jackson, Matthew A.
dc.contributor.author Jeffery, Ian B.
dc.contributor.author Beaumont, Michelle
dc.contributor.author Bell, Jordana T.
dc.contributor.author Clark, Andrew G.
dc.contributor.author Ley, Ruth E.
dc.contributor.author O'Toole, Paul W.
dc.contributor.author Spector, Tim D.
dc.contributor.author Steves, Claire J.
dc.date.accessioned 2017-02-22T13:01:33Z
dc.date.available 2017-02-22T13:01:33Z
dc.date.issued 2016-01-29
dc.identifier.citation Jackson, M. A., Jeffery, I. B., Beaumont, M., Bell, J. T., Clark, A. G., Ley, R. E., O’Toole, P. W., Spector, T. D. and Steves, C. J. (2016) 'Signatures of early frailty in the gut microbiota', Genome Medicine, 8(1), pp. 8. doi:10.1186/s13073-016-0262-7 en
dc.identifier.volume 8 en
dc.identifier.issued 1 en
dc.identifier.startpage 8-1 en
dc.identifier.endpage 8-11 en
dc.identifier.issn 1756-994X
dc.identifier.uri http://hdl.handle.net/10468/3669
dc.identifier.doi 10.1186/s13073-016-0262-7
dc.description.abstract Background: Frailty is arguably the biggest problem associated with population ageing, and associates with gut microbiome composition in elderly and care-dependent individuals. Here we characterize frailty associations with the gut microbiota in a younger community dwelling population, to identify targets for intervention to encourage healthy ageing. Method: We analysed 16S rRNA gene sequence data derived from faecal samples obtained from 728 female twins. Frailty was quantified using a frailty index (FI). Mixed effects models were used to identify associations with diversity, operational taxonomic units (OTUs) and taxa. OTU associations were replicated in the Eldermet cohort. Phenotypes were correlated with modules of OTUs collapsed by co-occurrence. Results: Frailty negatively associated with alpha diversity of the gut microbiota. Models considering a number of covariates identified 637 OTUs associated with FI. Twenty-two OTU associations were significant independent of alpha diversity. Species more abundant with frailty included Eubacterium dolichum and Eggerthella lenta. A Faecalibacterium prausnitzii OTU was less abundant in frailer individuals, and retained significance in discordant twin analysis. Sixty OTU associations were replicated in the Eldermet cohort. OTU co-occurrence modules had mutually exclusive associations between frailty and alpha diversity. Conclusions: There was a striking negative association between frailty and gut microbiota diversity, underpinned by specific taxonomic associations. Whether these relationships are causal or consequential is unknown. Nevertheless, they represent targets for diagnostic surveillance, or for intervention studies to improve vitality in ageing. en
dc.description.sponsorship The TwinsUK microbiota project was funded by the National Institutes of Health (NIH) RO1 DK093595, DP2 OD007444. TwinsUK received funding from the Wellcome Trust, European Community’s Seventh Framework Programme (FP7/2007-2013), the National Institute for Health Research (NIHR)-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. CJS is funded under a grant from the Chronic Disease Research Foundation (CDRF). Science Foundation Ireland (SFI) funds work in IBJ and PWOTs labs. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BioMed Central en
dc.rights © 2016 Jackson et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Frailty en
dc.subject Population ageing en
dc.subject Gut microbiota en
dc.subject Diagnostic surveillance en
dc.subject Intervention studies en
dc.title Signatures of early frailty in the gut microbiota en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul O'Toole, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: pwotoole@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-02-22T12:40:51Z
dc.description.version Published Version en
dc.internal.rssid 384563556
dc.contributor.funder National Institutes of Health en
dc.contributor.funder Wellcome Trust en
dc.contributor.funder European Commission en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder Kings College London en
dc.contributor.funder National Institute for Health Research en
dc.contributor.funder Guy's and St Thomas' NHS Foundation Trust en
dc.contributor.funder Chronic Disease Research Foundation (CDRF), United Kingdom en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Genome Medicine en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress pwotoole@ucc.ie en


Files in this item

This item appears in the following Collection(s)

Show simple item record

© 2016 Jackson et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Except where otherwise noted, this item's license is described as © 2016 Jackson et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement