Comparative genomics and functional analysis of the 936 group of lactococcal Siphoviridae phages

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dc.contributor.author Murphy, James
dc.contributor.author Bottacini, Francesca
dc.contributor.author Mahony, Jennifer
dc.contributor.author Kelleher, Philip
dc.contributor.author Neve, Horst
dc.contributor.author Zomer, Aldert
dc.contributor.author Nauta, Arjen
dc.contributor.author van Sinderen, Douwe
dc.date.accessioned 2017-02-23T12:33:05Z
dc.date.available 2017-02-23T12:33:05Z
dc.date.issued 2016-02-19
dc.identifier.citation Murphy, J., Bottacini, F., Mahony, J., Kelleher, P., Neve, H., Zomer, A., Nauta, A. and van Sinderen, D. (2016) 'Comparative genomics and functional analysis of the 936 group of lactococcal Siphoviridae phages', Scientific Reports, 6, pp. 21345. doi:10.1038/srep21345 en
dc.identifier.volume 6 en
dc.identifier.startpage 21345-1 en
dc.identifier.endpage 21345-13 en
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10468/3676
dc.identifier.doi 10.1038/srep21345
dc.description.abstract Genome sequencing and comparative analysis of bacteriophage collections has greatly enhanced our understanding regarding their prevalence, phage-host interactions as well as the overall biodiversity of their genomes. This knowledge is very relevant to phages infecting Lactococcus lactis, since they constitute a significant risk factor for dairy fermentations. Of the eighty four lactococcal phage genomes currently available, fifty five belong to the so-called 936 group, the most prevalent of the ten currently recognized lactococcal phage groups. Here, we report the genetic characteristics of a new collection of 936 group phages. By combining these genomes to those sequenced previously we determined the core and variable elements of the 936 genome. Genomic variation occurs across the 936 phage genome, such as genetic elements that (i) lead to a +1 translational frameshift resulting in the formation of additional structures on the phage tail, (ii) specify a double neck passage structure, and (iii) encode packaging module-associated methylases. Hierarchical clustering of the gene complement of the 936 group phages and nucleotide alignments allowed grouping of the ninety 936 group phages into distinct clusters, which in general appear to correspond with their geographical origin. en
dc.description.sponsorship Science Foundation Ireland (SFI Investigator award (Ref. No.13/IA/1953), SFI Technology Innovation Development Award (TIDA) (Ref. No. 14/TIDA/2287)); Irish Research Council (Enterprise Partnership Scheme postgraduate scholarship) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Nature Publishing Group en
dc.rights © 2016, The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Phage biology en
dc.subject Sequence annotation en
dc.subject Infection mechanism en
dc.subject Lytic bacteriophage en
dc.subject Gene expression en
dc.subject Receptor binding protein en
dc.title Comparative genomics and functional analysis of the 936 group of lactococcal Siphoviridae phages en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Douwe Van Sinderen, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: d.vansinderen@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-02-23T12:24:55Z
dc.description.version Published Version en
dc.internal.rssid 384690825
dc.internal.wokid WOS:000370566100001
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Irish Research Council en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Scientific Reports en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress d.vansinderen@ucc.ie en


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© 2016, The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ Except where otherwise noted, this item's license is described as © 2016, The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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