Dietary vitamin D2 - a potentially underestimated contributor to vitamin D nutritional status of adults?

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dc.contributor.author Cashman, Kevin D.
dc.contributor.author Kinsella, Michael
dc.contributor.author McNulty, Breige A.
dc.contributor.author Walton, Janette
dc.contributor.author Gibney, Michael J.
dc.contributor.author Flynn, Albert
dc.contributor.author Kiely, Mairead E.
dc.date.accessioned 2017-03-02T16:12:05Z
dc.date.available 2017-03-02T16:12:05Z
dc.date.issued 2014-04-29
dc.identifier.citation Cashman, K. D., Kinsella, M., McNulty, B. A., Walton, J., Gibney, M. J., Flynn, A. and Kiely, M. (2014) 'Dietary vitamin D2 – a potentially underestimated contributor to vitamin D nutritional status of adults?', British Journal of Nutrition, 112(2), pp. 193-202. doi:10.1017/S0007114514000725 en
dc.identifier.volume 112 en
dc.identifier.startpage 193 en
dc.identifier.endpage 202 en
dc.identifier.issn 0007-1145
dc.identifier.uri http://hdl.handle.net/10468/3733
dc.identifier.doi 10.1017/S0007114514000725
dc.description.abstract It has been suggested that vitamin D2 is not very prevalent in the human food chain. However, data from a number of recent intervention studies suggest that the majority of subjects had measurable serum 25-hydroxyvitamin D2 (25(OH)D2) concentrations. Serum 25(OH)D2, unlike 25(OH)D3, is not directly influenced by exposure of skin to sun and thus has dietary origins; however, quantifying dietary vitamin D2 is difficult due to the limitations of food composition data. Therefore, the present study aimed to characterise serum 25(OH)D2 concentrations in the participants of the National Adult Nutrition Survey (NANS) in Ireland, and to use these serum concentrations to estimate the intake of vitamin D2 using a mathematical modelling approach. Serum 25(OH)D2 concentration was measured by a liquid chromatography–tandem MS method, and information on diet as well as subject characteristics was obtained from the NANS. Of these participants, 78·7 % (n 884) had serum 25(OH)D2 concentrations above the limit of quantification, and the mean, maximum, 10th, 50th (median) and 90th percentile values of serum 25(OH)D2 concentrations were 3·69, 27·6, 1·71, 2·96 and 6·36 nmol/l, respectively. To approximate the intake of vitamin D2 from these serum 25(OH)D2 concentrations, we used recently published data on the relationship between vitamin D intake and the responses of serum 25(OH)D concentrations. The projected 5th to 95th percentile intakes of vitamin D2 for adults were in the range of 0·9–1·2 and 5–6 μg/d, respectively, and the median intake ranged from 1·7 to 2·3 μg/d. In conclusion, the present data demonstrate that 25(OH)D2 concentrations are present in the sera of adults from this nationally representative sample. Vitamin D2 may have an impact on nutritional adequacy at a population level and thus warrants further investigation. en
dc.description.sponsorship Higher Education Authority (Programme for Research in Third Level Institutions Cycle 4 (Food Ireland: National Food and Health Collaborative Research Programmes); Department of Agriculture, Food and the Marine (Food for Health Research Initiative (2007-12)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Cambridge University Press en
dc.rights © The Authors 2014. Published by Cambridge University Press (CUP) on behalf of The Nutrition Society en
dc.subject Serum 25-hydroxyvitamin D2 en
dc.subject Vitamin D2 en
dc.subject Distribution en
dc.subject Adults en
dc.subject Dietary sources en
dc.title Dietary vitamin D2 - a potentially underestimated contributor to vitamin D nutritional status of adults? en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Janette Walton, Firm Programme, University College Cork, Cork, Ireland. +353-21-490-3000 Email: janette.walton@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-03-02T16:04:03Z
dc.description.version Published Version en
dc.internal.rssid 256080691
dc.internal.pmid 24780068
dc.contributor.funder Higher Education Authority en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.description.status Peer reviewed en
dc.identifier.journaltitle British Journal of Nutrition en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress janette.walton@ucc.ie en


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