N-3 polyunsaturated fatty acids through the lifespan: implication for psychopathology

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dc.contributor.author Pusceddu, Matteo M.
dc.contributor.author Kelly, Philip
dc.contributor.author Stanton, Catherine
dc.contributor.author Cryan, John F.
dc.contributor.author Dinan, Timothy G.
dc.date.accessioned 2017-03-13T13:33:09Z
dc.date.available 2017-03-13T13:33:09Z
dc.date.issued 2016-09-08
dc.identifier.citation Pusceddu, M. M., Kelly, P., Stanton, C., Cryan, J. F. and Dinan, T. G. (2016) ‘N-3 polyunsaturated fatty acids through the lifespan: implication for psychopathology’, International Journal of Neuropsychopharmacology, 19(12), pp. 1-23. doi:10.1093/ijnp/pyw078 en
dc.identifier.volume 19 en
dc.identifier.issued 12 en
dc.identifier.startpage 1 en
dc.identifier.endpage 23 en
dc.identifier.issn 1461-1457
dc.identifier.uri http://hdl.handle.net/10468/3773
dc.identifier.doi 10.1093/ijnp/pyw078
dc.description.abstract Objective: The impact of lifetime dietary habits and their role in physical, mental, and social well-being has been the focus of considerable recent research. Omega-3 polyunsaturated fatty acids as a dietary constituent have been under the spotlight for decades. Omega-3 polyunsaturated fatty acids constitute key regulating factors of neurotransmission, neurogenesis, and neuroinflammation and are thereby fundamental for development, functioning, and aging of the CNS. Of note is the fact that these processes are altered in various psychiatric disorders, including attention deficit hyperactivity disorder, depression, and Alzheimer’s disease. Design: Relevant literature was identified through a search of MEDLINE via PubMed using the following words, “n-3 PUFAs,” “EPA,” and “DHA” in combination with “stress,” “cognition,” “ADHD,” “anxiety,” “depression,” “bipolar disorder,” “schizophrenia,” and “Alzheimer.” The principal focus was on the role of omega-3 polyunsaturated fatty acids throughout the lifespan and their implication for psychopathologies. Recommendations for future investigation on the potential clinical value of omega-3 polyunsaturated fatty acids were examined. Results: The inconsistent and inconclusive results from randomized clinical trials limits the usage of omega-3 polyunsaturated fatty acids in clinical practice. However, a body of literature demonstrates an inverse correlation between omega-3 polyunsaturated fatty acid levels and quality of life/ psychiatric diseases. Specifically, older healthy adults showing low habitual intake of omega-3 polyunsaturated fatty acids benefit most from consuming them, showing improved age-related cognitive decline. Conclusions: Although further studies are required, there is an exciting and growing body of research suggesting that omega-3 polyunsaturated fatty acids may have a potential clinical value in the prevention and treatment of psychopathologies. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Oxford University Press en
dc.rights © 2016, the Authors. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject Placebo-controlled trial en
dc.subject Randomized controlled trial en
dc.subject Attention-deficit/hyperactivity disorder en
dc.subject Ethyl-eicosapentaenoic acid en
dc.subject Fish oil supplementation en
dc.subject Brain docosahexaenoic acid en
dc.subject Major depressive disorder en
dc.subject Mild cognitive impairment en
dc.subject Healthy young adults en
dc.subject Long-chain omega 3 fatty acids en
dc.subject n-3 PUFAs en
dc.subject Depression en
dc.subject Schizophrenia en
dc.subject Bipolar disorder en
dc.subject Alzheimer’s disease en
dc.title N-3 polyunsaturated fatty acids through the lifespan: implication for psychopathology en
dc.type Review en
dc.internal.authorcontactother Ted Dinan, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.dinan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-03-13T13:18:40Z
dc.description.version Published Version en
dc.internal.rssid 386981755
dc.internal.wokid WOS:000393912800005
dc.description.status Peer reviewed en
dc.identifier.journaltitle International Journal of Neuropsychopharmacology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.placepublication Oxford en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.identifier.articleid pyw078


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© 2016, the Authors. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Except where otherwise noted, this item's license is described as © 2016, the Authors. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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