Bifidobacterium breve with a-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat

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dc.contributor.author Patterson, Elaine
dc.contributor.author Wall, Rebecca
dc.contributor.author Lisai, Sara
dc.contributor.author Ross, R. Paul
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.contributor.author Fitzgerald, Gerald F.
dc.contributor.author Banni, Sebastiano
dc.contributor.author Quigley, Eamonn M.
dc.contributor.author Shanahan, Fergus
dc.contributor.author Stanton, Catherine
dc.date.accessioned 2017-03-15T11:59:20Z
dc.date.available 2017-03-15T11:59:20Z
dc.date.issued 2017-03-07
dc.identifier.citation Patterson, E., Wall, R., Lisai, S., Ross, R. P., Dinan, T. G., Cryan, J. F., Fitzgerald, G. F., Banni, S., Quigley, E. M., Shanahan, F. and Stanton, C. (2017) 'Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat', Scientific Reports, 7, pp. 43300. doi:10.1038/srep43300 en
dc.identifier.volume 7 en
dc.identifier.startpage 43300-1 en
dc.identifier.endpage 43300-12 en
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10468/3785
dc.identifier.doi 10.1038/srep43300
dc.description.abstract This study focused on the mechanisms that fatty acid conjugating strains - Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in combination with B. breve NCIMB 702258 or B. breve DPC 6330 (109 CFU/day) or unsupplemented control diet for six weeks. The overall n-3 PUFA score was increased in all groups receiving the ALA enriched diet. Hepatic peroxisomal beta oxidation increased following supplementation of the ALA enriched diet with B. breve (P < 0.05) and so the ability of the strains to produce c9t11 conjugated linoleic acid (CLA) was identified in adipose tissue. Furthermore, a strain specific effect of B. breve NCIMB 702258 was found on the endocannabinoid system (ECS). Liver triglycerides (TAG) were reduced following ALA supplementation, compared with unsupplemented controls (P < 0.01) while intervention with B. breve further reduced liver TAG (P < 0.01), compared with the ALA enriched control. These data indicate that the interactions of the gut microbiota with fatty acid metabolism directly affect host health by modulating n-3 PUFA score and the ECS. en
dc.description.sponsorship Science Foundation Ireland (Grant no. SFI/12/RC/2273) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © The Authors 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Applied microbiology en
dc.subject Clinical microbiology en
dc.subject Experimental models of disease en
dc.title Bifidobacterium breve with a-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Catherine Stanton, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: catherine.stanton@teagasc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-03-15T11:54:33Z
dc.description.version Published Version en
dc.internal.rssid 387236311
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Scientific Reports en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress catherine.stanton@teagasc.ie en


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© The Authors 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ Except where otherwise noted, this item's license is described as © The Authors 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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