• Investigating neuronal calcium homeostasis in murine models of Alzheimer’s disease 

  Kaar, Aidan (University College Cork, 2019)

  This thesis is primarily concerned with the pathological remodelling of calcium homeostasis and signalling in murine Alzheimer’s disease (AD) models, namely the 3xTg-AD (APPSWE/PS1M146V/TauP301L) mouse and TgF344-AD ...
• Rationalising antipsychotic prescribing in dementia: a mixed-methods investigation 

  Walsh, Kieran (University College Cork, 2019)

  Introduction: Antipsychotics are commonly prescribed to people with dementia, especially in nursing homes, despite limited benefits and significant harms. There have been calls to better understand the reasons why ...
• The glutamatergic system and pain: influence of stress, oestrous cycle and gut microbiota 

  Sajjad, Jahangir (University College Cork, 2019)

  Women have a higher incidence of various visceral and neuropathic chronic pain conditions. Most of the animal studies investigating pain mechanisms show oestrogen to be pronociceptive. However, similar studies in healthy ...
• The impact of suicidal behaviour on family members in Ireland: a mixed methods study 

  Spillane, Ailbhe (University College Cork, 2019)

  Background: Suicidal behaviour is a complex and multifaceted problem encompassing individual, social and environmental components. There is a plethora of studies examining the adverse psychological health effects of suicide ...
• Biomarkers in Parkinson disease: studies on clinical, radiological and biological biomarkers 

  Crotty, Grace F. (University College Cork, 2018)

  Parkinson disease is the second most common neurodegenerative disorder after Alzheimer disease. It affects 2 to 3 percent of those over 65 years with an age-dependent prevalence. Currently, the diagnosis of PD is hampered ...

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