Food for thought: The role of nutrition in the microbiota-gut–brain axis

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dc.contributor.author Oriach, Clara Seira
dc.contributor.author Robertson, Ruairi C.
dc.contributor.author Stanton, Catherine
dc.contributor.author Cryan, John F.
dc.contributor.author Dinan, Timothy G.
dc.date.accessioned 2017-04-11T15:44:31Z
dc.date.available 2017-04-11T15:44:31Z
dc.date.issued 2016-01-21
dc.identifier.citation Oriach, C. S., Robertson, R. C., Stanton, C., Cryan, J. F. and Dinan, T. G. (2016) 'Food for thought: The role of nutrition in the microbiota-gut–brain axis', Clinical Nutrition Experimental, 6, pp. 25-38. doi:10.1016/j.yclnex.2016.01.003 en
dc.identifier.volume 6 en
dc.identifier.startpage 25 en
dc.identifier.endpage 38 en
dc.identifier.issn 2352-9393
dc.identifier.uri http://hdl.handle.net/10468/3876
dc.identifier.doi 10.1016/j.yclnex.2016.01.003
dc.description.abstract Recent research has provided strong evidence for the role of the commensal gut microbiota in brain function and behaviour. Many potential pathways are involved in this bidirectional communication between the gut microbiota and the brain such as immune mechanisms, the vagus nerve and microbial neurometabolite production. Dysbiosis of gut microbial function has been associated with behavioural and neurophysical deficits, therefore research focused on developing novel therapeutic strategies to treat psychiatric disorders by targeting the gut microbiota is rapidly growing. Numerous factors can influence the gut microbiota composition such as health status, mode of birth delivery and genetics, but diet is considered among the most crucial factors impacting on the human gut microbiota from infancy to old age. Thus, dietary interventions may have the potential to modulate psychiatric symptoms associated with gut–brain axis dysfunction. Further clinical and in vivo studies are needed to better understand the mechanisms underlying the link between nutrition, gut microbiota and control of behaviour and mental health. en
dc.description.sponsorship Science Foundation Ireland (centre grant, APC Microbiome Institute grant number SFI/12/RC/2273); Health Research Board, Ireland (Grant Numbers HRA_POR/2011/23 and HRA_POR/2012/32); Marine Institute (Sea Change Strategy); Teagasc (NutraMara programme (Grant-Aid Agreement No. MFFRI/07/01)); Enterprise Ireland (SMART FOOD project: ‘Science Based ‘Intelligent’/Functional and Medical Foods for Optimum Brain Health, Targeting Depression and Cognition’ project (Ref No. 13/F/411) with the support of the Marine Institute and the Department of Agriculture, Food and the Marine (DAFM) in Ireland) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism en
dc.rights © 2016 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Diet en
dc.subject Psychobiotics en
dc.subject Gut microbiota en
dc.subject Psychiatric disorders en
dc.subject Gut-brain axis en
dc.title Food for thought: The role of nutrition in the microbiota-gut–brain axis en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ted Dinan, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.dinan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-04-11T15:29:26Z
dc.description.version Published Version en
dc.internal.rssid 390799357
dc.internal.rssid 478578997
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Marine Institute en
dc.contributor.funder Teagasc en
dc.contributor.funder Enterprise Ireland en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Clinical Nutrition Experimental en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.internal.IRISemailaddress brendan.griffin@ucc.ie en


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© 2016 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Except where otherwise noted, this item's license is described as © 2016 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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