Comparative and functional genomics of the Lactococcus lactis taxon; insights into evolution and niche adaptation

cb
Thumbnail Image
Files
2815.pdf(3.03 MB)
Published Version
Date
2017-03-29
Authors
Kelleher, Philip
Bottacini, Francesca
Mahony, Jennifer
Kilcawley, Kieran N.
van Sinderen, Douwe
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Published Version
10.1186/s12864-017-3650-5
Research Projects
Organizational Units
Journal Issue
Abstract
Background: Lactococcus lactis is among the most widely studied lactic acid bacterial species due to its long history of safe use and economic importance to the dairy industry, where it is exploited as a starter culture in cheese production. Results: In the current study, we report on the complete sequencing of 16 L. lactis subsp. lactis and L. lactis subsp. cremoris genomes. The chromosomal features of these 16 L. lactis strains in conjunction with 14 completely sequenced, publicly available lactococcal chromosomes were assessed with particular emphasis on discerning the L. lactis subspecies division, evolution and niche adaptation. The deduced pan-genome of L. lactis was found to be closed, indicating that the representative data sets employed for this analysis are sufficient to fully describe the genetic diversity of the taxon. Conclusions: Niche adaptation appears to play a significant role in governing the genetic content of each L. lactis subspecies, while (differential) genome decay and redundancy in the dairy niche is also highlighted.
Description
Keywords
Lactococcus lactis , Genomics , SMRT sequencing , Pan-genome , Niche adaptation
Citation
Kelleher, P., Bottacini, F., Mahony, J., Kilcawley, K. N. and van Sinderen, D. (2017) 'Comparative and functional genomics of the Lactococcus lactis taxon; insights into evolution and niche adaptation', BMC Genomics, 18, 267 (20pp). doi: 10.1186/s12864-017-3650-5
Link to publisher’s version
URI
https://hdl.handle.net/10468/3911
Collections
Microbiology - Journal Articles
APC Microbiome Ireland - Journal Articles
Copyright
© 2017, the Authors. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.