Fabrication and characterization of microfabricated on-chip microelectrochemical cell for biosensing applications

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dc.contributor.author Mohd Said, Nur Azura
dc.contributor.author Twomey, Karen
dc.contributor.author Herzog, G.
dc.contributor.author Ogurtsov, Vladimir I.
dc.date.accessioned 2017-05-15T12:04:18Z
dc.date.available 2017-05-15T12:04:18Z
dc.date.issued 2017-03-13
dc.identifier.citation Said, N. A. M., Twomey, K., Herzog, G. and Ogurtsov, V. I. (2017) ‘Fabrication and characterization of microfabricated on-chip microelectrochemical cell for biosensing applications’, AIP Conference Proceedings, 1808, 020032 (13pp). doi: 10.1063/1.4975265 en
dc.identifier.volume 1808 en
dc.identifier.startpage 1 en
dc.identifier.endpage 13 en
dc.identifier.issn 0094-243X
dc.identifier.uri http://hdl.handle.net/10468/3965
dc.identifier.doi 10.1063/1.4975265
dc.description.abstract The fabrication of on-chip microelectrochemical cell on Si wafer by means of photolithography is described here. The single on-chip microelectrochemical cell device has dimensions of 100 × 380 mm with integrated Pt counter electrode (CE), Ag/AgCl reference electrode (RE) and gold microelectrode array of 500 nm recess depth as the working electrode (WE). Two geometries of electrode array were implemented, band and disc, with fixed diameter/width of 10 µm; and varied centre-to-centre spacing (d) and number of electrodes (N) in the array. The on-chip microelectrochemical cell structure has been designed to facilitate further WE biomodifications. Firstly, the developed microelectrochemical cell does not require packaging hence reducing the production cost and time. Secondly, the working electrode (WE) on the microelectrochemical cell is positioned towards the end of the chip enabling modification of the working electrode surface to be carried out for surface bio-functionalisation without affecting both the RE and CE surface conditions. The developed on-chip microelectrochemical cell was examined with scanning electron microscopy (SEM) and characterised by two electrochemical techniques. Both cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were performed in 1 mM ferrocenecarboxylic acid (FCA) in 0.01 M phosphate buffered saline (PBS) solution at pH7.4. Electrochemical experiments showed that in the case of halving the interspacing distance of the microdisc WE array (50 nm instead of 100 nm), the voltammogram shifted from a steady-state CV (feature of hemispherical diffusion) to an inclined peak-shaped CV (feature of linear diffusion) albeit the arrays had the same surface area. In terms of EIS it was also found that linear diffusion dominates the surface instead of hemispherical diffusion once the interspacing distance was reduced, supporting the fact that closely packed arrays may behave like a macroelectrode. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher AIP Publishing en
dc.relation.ispartof 11th Asian Conference on Chemical Sensors (ACCS2015)
dc.rights © 2017, the Authors. Reproduced with the permission of AIP Publishing from AIP Conference Proceedings, 1808, 020032 (13pp). doi: 10.1063/1.4975265 en
dc.subject Linear diffusion en
dc.subject Macroelectrode en
dc.subject Voltammogram en
dc.title Fabrication and characterization of microfabricated on-chip microelectrochemical cell for biosensing applications en
dc.type Conference item en
dc.internal.authorcontactother Karen Twomey, Tyndall Microsystems, University College Cork, Cork, Ireland. +353-21-490-3000 Email: karen.twomey@tyndall.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2018-03-13
dc.date.updated 2017-05-15T11:49:04Z
dc.description.version Published Version en
dc.internal.rssid 395124893
dc.contributor.funder Seventh Framework Programme en
dc.description.status Peer reviewed en
dc.identifier.journaltitle AIP Conference Proceedings en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.conferencelocation Penang, Malaysia en
dc.internal.IRISemailaddress karen.twomey@tyndall.ie en
dc.identifier.articleid 020032
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::NMP/228685/EU/BIOELECTRONIC OLFACTORY NEURON DEVICE/BOND en

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