Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse

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Show simple item record Scott, Karen A. Ida, Masayuki Peterson, Veronica L. Prenderville, Jack A. Moloney, Gerard M. Izumo, Takayuki Murphy, Kiera Murphy, Amy Ross, R. Paul Stanton, Catherine Dinan, Timothy G. Cryan, John F. 2017-06-02T11:33:19Z 2017-06-02T11:33:19Z 2017-02-04
dc.identifier.citation Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., Dinan, T. G. and Cryan, J. F. (2017) 'Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse', Brain, Behavior, and Immunity, 65, pp. 20-32. doi:10.1016/j.bbi.2017.02.004 en
dc.identifier.volume 65
dc.identifier.startpage 20
dc.identifier.endpage 32
dc.identifier.issn 0889-1591
dc.identifier.doi 10.1016/j.bbi.2017.02.004
dc.description.abstract Over the last decade, there has been increased interest in the role of the gut microbiome in health including brain health. This is by no means a new theory; Elie Metchnikoff proposed over a century ago that targeting the gut by consuming lactic acid bacteria such as those in yogurt, could improve or delay the onset of cognitive decline associated with ageing. However, there is limited information characterising the relationship between the behavioural and physiological sequelae of ageing and alterations in the gut microbiome. To this end, we assessed the behavioural, physiological and caecal microbiota profile of aged male mice. Older mice (20–21 months old) exhibited deficits in spatial memory and increases in anxiety-like behaviours compared to younger mice (2–3 months old). They also exhibited increased gut permeability, which was directly correlated with elevations in peripheral pro-inflammatory cytokines. Furthermore, stress exacerbated the gut permeability of aged mice. Examination of the caecal microbiota revealed significant increases in phylum TM7, family Porphyromonadaceae and genus Odoribacter of aged mice. This represents a shift of aged microbiota towards a profile previously associated with inflammatory disease, particularly gastrointestinal and liver disorders. Furthermore, Porphyromonadaceae, which has also been associated with cognitive decline and affective disorders, was directly correlated with anxiety-like behaviour in aged mice. These changes suggest that changes in the gut microbiota and associated increases in gut permeability and peripheral inflammation may be important mediators of the impairments in behavioural, affective and cognitive functions seen in ageing. en
dc.description.sponsorship Science Foundation Ireland (SFI funded research centre, APC Microbiome Institute through the Irish Government’s National Development Plan (Grant Number 12/RC/2273) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2017 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri en
dc.subject Microbiota en
dc.subject Microbiota-gut-brain axis en
dc.subject Ageing en
dc.subject Inflammation en
dc.subject Anxiety en
dc.subject Behaviour en
dc.subject Cognitive impairment en
dc.subject Gut permeability en
dc.title Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F Cryan, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en Access to this article is restricted until 12 months after publication at the request of the publisher en 2018-02-04 2017-06-02T11:19:21Z
dc.description.version Accepted Version en
dc.internal.rssid 397415109
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder Mead Johnson Nutrition en
dc.contributor.funder Suntory Wellness Ltd. Japan en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Brain, Behavior, and Immunity en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en

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© 2017 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2017 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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