Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status

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dc.contributor.author Scott, Karen A.
dc.contributor.author de Kloet, Annette D.
dc.contributor.author Smeltzer, Michael D.
dc.contributor.author Krause, Eric G.
dc.contributor.author Flak, Jonathan N.
dc.contributor.author Melhorn, Susan J.
dc.contributor.author Foster, Michelle T.
dc.contributor.author Tamashiro, Kellie L. K.
dc.contributor.author Sakai, Randall R.
dc.date.accessioned 2017-06-07T15:51:30Z
dc.date.available 2017-06-07T15:51:30Z
dc.date.issued 2017-03-08
dc.identifier.citation Scott, K. A., de Kloet, A. D., Smeltzer, M. D., Krause, E. G., Flak, J. N., Melhorn, S. J., Foster, M. T., Tamashiro, K. L. K. and Sakai, R. R. 'Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status', Physiology & Behavior. doi:10.1016/j.physbeh.2017.03.006 In Press en
dc.identifier.issn 0031-9384
dc.identifier.uri http://hdl.handle.net/10468/4059
dc.identifier.doi 10.1016/j.physbeh.2017.03.006
dc.description.abstract Mood disorders such as major depressive disorder (MDD) affect a significant proportion of the population. Although progress has been made in the development of therapeutics, a large number of individuals do not attain full remission of symptoms and adverse side effects affect treatment compliance for some. In order to develop new therapies, there is a push for new models that better reflect the multiple risk factors that likely contribute to the development of depressive illness. We hypothesized that early life stress would exacerbate the depressive-like phenotype that we have previously observed in socially subordinate (SUB) adult male rats in the visible burrow system (VBS), a semi-natural, ethologically relevant environment in which males in a colony form a dominance hierarchy. Dams were exposed to chronic variable stress (CVS) during the last week of gestation, resulting in a robust and non-habituating glucocorticoid response that did not alter maternal food intake, body weight or litter size and weight. As adults, one prenatal CVS (PCVS) and one non-stressed (NS) male were housed in the VBS with adult females. Although there were no overt differences between PCVS and NS male offspring prior to VBS housing, a greater percentage of PCVS males became SUB. However, the depressive-like phenotype of SUB males was not exacerbated in PCVS males; rather, they appeared to better cope with SUB status than NS SUB males. They had lower basal plasma corticosterone than NS SUB males at the end of VBS housing. In situ hybridization for CRH in the PVN and CeA did not reveal any prenatal treatment or status effects, while NPY expression was higher within the MeA of dominant and subordinate males exposed to the VBS in comparison with controls, but with no effect of prenatal treatment. These data suggest that prenatal chronic variable stress may confer resilience to offspring when exposed to social stress in adulthood. en
dc.description.sponsorship National Institutes of Health (NIH grants MH088230 and DK068273) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2017 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Mood disorders en
dc.subject Major depressive disorder en
dc.subject Social stress en
dc.subject Resilience en
dc.subject Risk factors en
dc.title Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Karen A. Scott, Anatomy and Neuroscience, University College Cork, Cork, Ireland. T: +353 21 490 3000, E: k.scott@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication at the request of the publisher en
dc.check.date 2018-03-08
dc.description.version Accepted Version en
dc.contributor.funder National Institutes of Health en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Physiology & Behavior en
dc.internal.IRISemailaddress k.scott@ucc.ie en


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© 2017 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2017 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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