The effect of high-dose vitamin D supplementation on muscular function and quality of life in postmenopausal women—A randomized controlled trial

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dc.contributor.author Grimnes, Guri
dc.contributor.author Emaus, Nina
dc.contributor.author Cashman, Kevin D.
dc.contributor.author Jorde, Rolf
dc.date.accessioned 2017-06-08T14:40:23Z
dc.date.available 2017-06-08T14:40:23Z
dc.date.issued 2017-05-11
dc.identifier.citation Grimnes, G., Emaus, N., Cashman, K. D. and Jorde, R. 'The effect of high-dose vitamin D supplementation on muscular function and quality of life in postmenopausal women—A randomized controlled trial', Clinical Endocrinology, doi:10.1111/cen.13353 In Press en
dc.identifier.issn 1365-2265
dc.identifier.uri http://hdl.handle.net/10468/4066
dc.identifier.doi 10.1111/cen.13353
dc.description.abstract Objective: Observational studies have suggested positive associations between serum 25-hydroxyvitamin D (25(OH)D) levels and muscular strength, balance and quality of life. Our aim was to examine whether high-dose vitamin D supplementation would improve these measures as compared to standard-dose vitamin D, as well as the possible muscular effects of single nucleotide polymorphisms (SNPs) in genes encoding vitamin D-related enzymes. Design: A 12-month randomized, double-blind, controlled trial where the participants received daily elemental calcium (1000 mg) plus vitamin D3 (800 IU). In addition, the participants were randomized to receive either capsules with vitamin D3 (20 000 IU) or matching placebos to be taken twice a week. Patients: A total of 297 postmenopausal women with osteopenia or osteoporosis. Measurements: Muscle strength (handgrip and knee extensor strength), balance (tandem test) and quality of life (EQ-5D) were measured at baseline and after 12 months. The subjects were genotyped for SNPs related to vitamin D metabolism. Results: Of the 297 included women, 275 completed the study. Mean serum 25(OH)D levels dramatically increased in the high-dose group (from 64.7 to 164.1 nmol/L; P<.01), while a more moderate increased was observed in the standard-dose group (from 64.1 to 81.8 nmol/L; P<.01). There was no significant difference between the groups in change in muscular strength, balance or quality of life over the intervention period. Polymorphisms in rs3829251 (located in the 7-dehydrocholesterol reductase gene) were associated with muscle strength and treatment effects. Conclusion: One-year treatment with high-dose vitamin D had no effect on muscular strength, balance or quality of life in postmenopausal women with osteopenia or osteoporosis as compared to standard dose. The association between rs3829251 and muscle strength needs confirmation in other populations. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.rights © 2017 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: The effect of high-dose vitamin D supplementation on muscular function and quality of life in postmenopausal women—A randomized controlled trial. Clin Endocrinol. 2017, which has been published in final form at http://dx.doi.org/10.1111/cen.13353. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Muscle strength en
dc.subject Quality of life en
dc.subject Randomized controlled trial en
dc.subject Single nucleotide polymorphisms en
dc.subject Vitamin D en
dc.title The effect of high-dose vitamin D supplementation on muscular function and quality of life in postmenopausal women—A randomized controlled trial en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Kevin Cashman, Dept Of Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: k.cashman@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication at the request of the publisher. en
dc.check.date 2018-05-11
dc.date.updated 2017-06-08T14:25:47Z
dc.description.version Accepted Version en
dc.internal.rssid 398178509
dc.contributor.funder Norske Kvinners Sanitetsforening en
dc.contributor.funder European Commission en
dc.contributor.funder Seventh Framework Programme en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Clinical Endocrinology en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress k.cashman@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODIN en


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