Toxicity assessment of ZnO-decorated Au nanoparticles in the Mediterranean clam Ruditapes decussatus

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dc.contributor.author Sellami, Badreddine
dc.contributor.author Mezni, Amine
dc.contributor.author Khazri, Abdelhafidh
dc.contributor.author Bouzidi, Imen
dc.contributor.author Saidani, Wiem
dc.contributor.author Sheehan, David
dc.contributor.author Beyrem, Hamouda
dc.date.accessioned 2017-06-19T13:42:35Z
dc.date.available 2017-06-19T13:42:35Z
dc.date.issued 2017-04-15
dc.identifier.citation Sellami, B., Mezni, A., Khazri, A., Bouzidi, I., Saidani, W., Sheehan, D. and Beyrem, H. (2017) 'Toxicity assessment of ZnO-decorated Au nanoparticles in the Mediterranean clam Ruditapes decussatus', Aquatic Toxicology, 188, pp. 10-19. doi:10.1016/j.aquatox.2017.04.005 en
dc.identifier.volume 188 en
dc.identifier.startpage 10 en
dc.identifier.endpage 19 en
dc.identifier.issn 0166-445X
dc.identifier.uri http://hdl.handle.net/10468/4091
dc.identifier.doi 10.1016/j.aquatox.2017.04.005
dc.description.abstract The synthesis of hybrid nanomaterials has greatly increased in recent years due to their special physical and chemical properties. However, information regarding the environmental toxicity associated with these chemicals is limited, in particular in the aquatic environment. In the present study, an experiment was performed in which the marine bivalve (Ruditapes decussatus) was exposed for 14 days to 2 concentrations of zinc oxide-decorated Au nanoparticles (Au-ZnONPs: Au-ZnONP50 = 50 μg/L; Au-ZnONP100 = 100 μg/L). The stability and resistance of Au-ZnONPs in the natural seawater were assessed by combining transmission electron microscopy and dynamic light scattering. Inductively coupled plasma-atomic emission spectroscopy revealed uptake of these nanoparticles within clams and their ability to induce metallic deregulation. The results obtained indicate that Au-ZnONPs induce biochemical and histological alterations within either the digestive gland or gill tissues at high concentration. This was deduced from the significant increase in H2O2 level, superoxide dismutase and catalase activities and malondialdehyde content. Furthermore, the toxicity of Au-ZnO nanoparticles was linked with the increase of intracellular iron and calcium levels in both tissues. Histological alterations in gill and digestive gland were more pronounced with Au-ZnONP100 and this is likely related to oxidative mechanisms. Gill and digestive gland are differentially sensitive to Au-ZnONPs if the exposure concentration is higher than 50 μg/L. In conclusion, the parameters considered here could constitute reliable biomarkers for evaluation of hybrid nanoparticles toxicity in environmental model organisms. In addition, based on the results obtained, gill and digestive gland of R. decussatus could be proposed as models to detect harmful effects of hybrid nanoparticles. en
dc.description.sponsorship National Institute of Marine Sciences and Technologies, Tunisia; The Ministry of Higher Education of Carthage, Tunisia; Laboratory of Environment Biomonitoring; Department of Chemistry, Faculty of Sciences of Bizerte, University of Carthage, Tunisia; Environmental Research Institute and School of Biochemistry and Cell Biology, University College Cork. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2017 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject ZnO-decorated Au nanoparticles en
dc.subject Ruditapes decussatus en
dc.subject Biomarkers en
dc.subject Oxidative stress en
dc.title Toxicity assessment of ZnO-decorated Au nanoparticles in the Mediterranean clam Ruditapes decussatus en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother David Sheehan, School Of Biochemistry & Cell Biology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: d.sheehan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 24 months after publication at the request of the publisher. en
dc.check.date 2019-04-15
dc.date.updated 2017-06-19T13:29:25Z
dc.description.version Accepted Version en
dc.internal.rssid 399705044
dc.contributor.funder University College Cork en
dc.contributor.funder National Institute of Marine Sciences and Technologies, Tunisia
dc.contributor.funder Ministry of Higher Education of Carthage, Tunisia
dc.contributor.funder University of Carthage
dc.description.status Peer reviewed en
dc.identifier.journaltitle Aquatic Toxicology en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress d.sheehan@ucc.ie en


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© 2017 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2017 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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