Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics

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dc.contributor.author Leary, Eileen M.
dc.contributor.author Jones, David J.
dc.contributor.author O'Donovan, Fiona P.
dc.contributor.author O'Sullivan, Timothy P.
dc.date.accessioned 2017-06-20T15:36:58Z
dc.date.available 2017-06-20T15:36:58Z
dc.date.issued 2015-06-11
dc.identifier.citation O’Leary, E. M., Jones, D. J., O’Donovan, F. P. and O'Sullivan, T. P. (2015) 'Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics', Journal of Fluorine Chemistry, 176, pp. 93-120. doi: 10.1016/j.jfluchem.2015.06.002 en
dc.identifier.volume 176 en
dc.identifier.startpage 93 en
dc.identifier.endpage 120 en
dc.identifier.issn 0022-1139
dc.identifier.uri http://hdl.handle.net/10468/4118
dc.identifier.doi doi:10.1016/j.jfluchem.2015.06.002
dc.description.abstract Milk protein concentrate (79% protein) reconstituted at 13.5% (w/v) protein was heated (90 °C, 25 min, pH 7.2) with or without added calcium chloride. After fractionation of the casein and whey protein aggregates by fast protein liquid chromatography, the heat stability (90 °C, up to 1 h) of the fractions (0.25%, w/v, protein) was assessed. The heat-induced aggregates were composed of whey protein and casein, in whey protein:casein ratios ranging from 1:0.5 to 1:9. The heat stability was positively correlated with the casein concentration in the samples. The samples containing the highest proportion of caseins were the most heat-stable, and close to 100% (w/w) of the aggregates were recovered post-heat treatment in the supernatant of such samples (centrifugation for 30 min at 10,000 × g). κ-Casein appeared to act as a chaperone controlling the aggregation of whey proteins, and this effect was stronger in the presence of αS- and β-casein. en
dc.description.sponsorship University College Cork (Strategic Research Fund) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2015 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Organofluorine chemistry en
dc.subject Fluorobenzofurans en
dc.subject Fluoropyrones en
dc.subject Fluorocoumarins en
dc.subject Fluoroflavones en
dc.subject Fluorochromones en
dc.subject Fluoroxanthones en
dc.subject Fluorothiophenes en
dc.subject Fluorobenzothiophenes en
dc.title Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Tim O'Sullivan, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: tim.osullivan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-06-20T11:03:21Z
dc.description.version Accepted Version en
dc.internal.rssid 306781666
dc.contributor.funder Irish Research Council en
dc.contributor.funder University College Cork en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Fluorine Chemistry en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress tim.osullivan@ucc.ie en


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© 2015 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2015 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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