Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish

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dc.contributor.author Borrelli, Luca
dc.contributor.author Aceto, Serena
dc.contributor.author Agnisola, Claudio
dc.contributor.author De Paolo, Sofia
dc.contributor.author Dipineto, Ludovico
dc.contributor.author Stilling, Roman M.
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.contributor.author Menna, Lucia F.
dc.date.accessioned 2017-06-22T13:55:53Z
dc.date.available 2017-06-22T13:55:53Z
dc.date.issued 2016-07-15
dc.identifier.citation Borrelli, L., Aceto, S., Agnisola, C., De Paolo, S., Dipineto, L., Stilling, R. M., Dinan, T. G., Cryan, J. F., Menna, L. F. and Fioretti, A. (2016) 'Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish', Scientific Reports, 6, 30046 (9pp). doi: 10.1038/srep30046 en
dc.identifier.volume 6
dc.identifier.startpage 1
dc.identifier.endpage 9
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10468/4169
dc.identifier.doi 10.1038/srep30046
dc.description.abstract The gut microbiota plays a crucial role in the bi-directional gut–brain axis, a communication that integrates the gut and central nervous system (CNS) activities. Animal studies reveal that gut bacteria influence behaviour, Brain-Derived Neurotrophic Factor (BDNF) levels and serotonin metabolism. In the present study, we report for the first time an analysis of the microbiota–gut–brain axis in zebrafish (Danio rerio). After 28 days of dietary administration with the probiotic Lactobacillus rhamnosus IMC 501, we found differences in shoaling behaviour, brain expression levels of bdnf and of genes involved in serotonin signalling/metabolism between control and treated zebrafish group. In addition, in microbiota we found a significant increase of Firmicutes and a trending reduction of Proteobacteria. This study demonstrates that selected microbes can be used to modulate endogenous neuroactive molecules in zebrafish. en
dc.description.sponsorship Regione Campania (Fondo Sociale Europeo 2007/2013) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Nature Publishing Group en
dc.relation.uri https://www.nature.com/articles/srep30046
dc.rights © 2016, Borrelli et al. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Microbiome en
dc.subject Nutrition en
dc.title Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F. Cryan, APC Microbiome Institute, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.cryan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Regione Campania
dc.description.status Peer reviewed en
dc.identifier.journaltitle Scientific Reports en
dc.internal.IRISemailaddress j.cryan@ucc.ie en
dc.identifier.articleid 30046


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© 2016, Borrelli et al. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ Except where otherwise noted, this item's license is described as © 2016, Borrelli et al. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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